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Butylated hydroxytoluene/2,6-二叔丁基对甲酚 {[allProObj[0].p_purity_real_show]}

货号:A340728 同义名: BHT; NSC 6347

Butylated HCl 是一种抗氧化剂,广泛用于食品和与食品相关的产品中,也是一种铁死亡(Ferroptosis)抑制剂。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Butylated hydroxytoluene/2,6-二叔丁基对甲酚 化学结构 CAS号:128-37-0
Butylated hydroxytoluene/2,6-二叔丁基对甲酚 化学结构
CAS号:128-37-0
Butylated hydroxytoluene/2,6-二叔丁基对甲酚 3D分子结构
CAS号:128-37-0
Butylated hydroxytoluene/2,6-二叔丁基对甲酚 化学结构 CAS号:128-37-0
Butylated hydroxytoluene/2,6-二叔丁基对甲酚 3D分子结构 CAS号:128-37-0
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Butylated hydroxytoluene/2,6-二叔丁基对甲酚 纯度/质量文件 产品仅供科研

货号:A340728 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 Ferroptosis 其他靶点 纯度
Ferrostatin-1 ++

Ferroptosis, EC50: 60 nM

98%
Liproxstatin-1 +++

ferroptosis, IC50: 22 nM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Butylated hydroxytoluene/2,6-二叔丁基对甲酚 生物活性

描述 Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Butylated hydroxytoluene, an antioxidant widely used in foods and food-related products, is a ferroptosis inhibitor which blocks lipid peroxidation[4]. In weanling rats, butylated hydroxytoluene had a greater deleterious effect on the growth of the male than of the female rat, especially at the 0.5% dietary level. At this level, it also increased the relative weight of the liver. The enlarged liver showed a marked elevation in the concentration of total lipids and of both total and esterified cholesterol. Moreover, there were striking increases in the plasma total and esterified cholesterol and phospholipid levels in the butylated hydroxytoluene treated animals[5]. As as a potent promoter of carcinogen, butylated hydroxytoluene (400 mg/kg; orally) administration increased the susceptibility of 7-week-old rasH2 mice to lung carcinogens[6].

Butylated hydroxytoluene/2,6-二叔丁基对甲酚 参考文献

[1]Babich H, et al. Butylated hydroxytoluene (BHT): a review. Environ Res. 1982 Oct;29(1):1-29.

[2]Stockwell BR, et al. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. ell. 2017 Oct 5;171(2):273-285.

[3]Umemura T, et al. Butylhydroxytoluene (BHT) increases susceptibility of transgenic rasH2 mice to lung carcinogenesis. J Cancer Res Clin Oncol. 2001 Oct;127(10):583-90.

[4]Stockwell BR, Friedmann Angeli JP, Bayir H, et al. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell. 2017 Oct 5;171(2):273-285

[5]Saheb JL, Saheb SA. Toxic effects of butylated hydroxytoluene on rats. Can J Comp Med. 1977 Apr;41(2):195-201.

[6]Umemura T, Kodama Y, Hioki K, Inoue T, Nomura T, Kurokawa Y. Butylhydroxytoluene (BHT) increases susceptibility of transgenic rasH2 mice to lung carcinogenesis. J Cancer Res Clin Oncol. 2001 Oct;127(10):583-90.

Butylated hydroxytoluene/2,6-二叔丁基对甲酚 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.54mL

0.91mL

0.45mL

22.69mL

4.54mL

2.27mL

45.38mL

9.08mL

4.54mL

Butylated hydroxytoluene/2,6-二叔丁基对甲酚 技术信息

CAS号128-37-0
分子式C15H24O
分子量 220.35
SMILES Code CC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C
MDL No. MFCD00011644
别名 BHT; NSC 6347
运输蓝冰
InChI Key NLZUEZXRPGMBCV-UHFFFAOYSA-N
Pubchem ID 31404
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere, room temperature

溶解方案

DMSO: 105 mg/mL(476.51 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 1 mg/mL(4.54 mM),配合低频超声助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
配制的工作液建议现用现配,短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
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