Biotinylated Human SLAMF7 (C-6His-Avi, HEK293)
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货号：A2925722同义名：
重组生物素化人SLAMF7蛋白(C-6His-Avi, HEK293)
/ Biotinylated Human SLAMF7 (C-6His-Avi, HEK293); SLAM Family Member 7
Biotinylated Human SLAMF7 (C-6His-Avi, HEK293) 是来自人的蛋白，在 HEK293 人源细胞中表达，带有 C 端 6His 和 Avi 标签。该蛋白是一种单次跨膜Ⅰ型膜蛋白，含有一个 Ig 类 C2 结构域。主要表达在 NK 细胞与活化的 B 细胞中，能够通过活化途径 EAT - 2 或抑制因子调节 NK 细胞和 T 细胞的功能。
Biotinylated Human SLAMF7 (C-6His-Avi, HEK293) 化学结构 CAS号：N/A
Biotinylated Human SLAMF7 (C-6His-Avi, HEK293) 3D分子结构 CAS号：N/A
Biotinylated Human SLAMF7 (C-6His-Avi, HEK293) 质控信息
Biotinylated Human SLAMF7 (C-6His-Avi, HEK293) 生物活性
描述
SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Biotinylated Human SLAMF7 (C-6His-Avi, HEK293) 技术信息
CAS号
N/A
分子量
25.2 KDa
SMILES Code
NONE
别名
重组生物素化人SLAMF7蛋白(C-6His-Avi, HEK293)
;Biotinylated Human SLAMF7 (C-6His-Avi, HEK293); SLAM Family Member 7; CD2 Subset 1; CD2-Like Receptor-Activating Cytotoxic Cells; CRACC; Membrane Protein FOAP-12; Novel Ly9; Protein 19A; CD319; SLAMF7; CS1
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Biotinylated Human SLAMF7 (C-6His-Avi, HEK293)
|Biotinylated Human SLAMF7 (C-6His-Avi, HEK293)
| 重组生物素化人SLAMF7蛋白(C-6His-Avi, HEK293)
| SLAM Family Member 7
| CD2 Subset 1
| CD2-Like Receptor-Activating Cytotoxic Cells
| CRACC
| Membrane Protein FOAP-12
| Novel Ly9
| Protein 19A
| CD319
| SLAMF7
| CS1
| N/A
| Dendritic Cell CD Proteins
| CD319/SLAMF7
| Macrophage CD Proteins
| Monocyte CD Proteins
| Biotinylated Human SLAMF7 (C-6His-Avi, HEK293) 纯度/质量文件
| Biotinylated Human SLAMF7 (C-6His-Avi, HEK293) 生物活性
| Biotinylated Human SLAMF7 (C-6His-Avi, HEK293) 技术信息
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