Biotinylated Human HGF R (C-6His-Avi, HEK293)
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货号：A2925617同义名：
重组生物素化人HGF R蛋白(C-6His-Avi, HEK293)
/ Biotinylated Human HGF R (C-6His-Avi, HEK293); Hepatocyte growth factor receptor
Biotinylated Human HGF R (C-6His-Avi, HEK293) 是人源肝细胞生长因子受体（HGF R），在HEK293人源细胞中表达，带有C端6×His和Avi标签。该蛋白是一种糖基化的受体酪氨酸激酶，在上皮形态发生和肿瘤发展中起关键作用，其成熟形式为α与β链组成的二聚体，参与配体结合、受体二聚化及信号转导，刺激后可诱导内吞与降解，调控上皮细胞迁移与分支管腔形成。
Biotinylated Human HGF R (C-6His-Avi, HEK293) 化学结构 CAS号：N/A
Biotinylated Human HGF R (C-6His-Avi, HEK293) 3D分子结构 CAS号：N/A
Biotinylated Human HGF R (C-6His-Avi, HEK293) 质控信息
Biotinylated Human HGF R (C-6His-Avi, HEK293) 生物活性
描述
Hepatocyte growth factor receptor (HGF R) is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which undergoes cotranslational proteolytic cleavage. Mature HGF R is a disulfide-linked dimer composed of a 50 kDa extracellular α chain and a 145 kDa transmembrane β chain. Proteolysis and alternate splicing generate additional forms of human HGF R which either lack of the kinase domain, consist of secreted extracellular domains, or are deficient in proteolytic separation of the α and β chains. The sema domain, which is formed by both α and β chains of HGF R, mediates both ligand binding and receptor dimerization. HGF stimulation induces HGF R downregulation via internalization and proteasomedependent degradation. Paracrine induction of epithelial cell scattering and branching tubulogenesis results from the stimulation of HGF R on undifferentiated epithelium by HGF released from neighboring mesenchymal cells.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Biotinylated Human HGF R (C-6His-Avi, HEK293) 技术信息
CAS号
N/A
分子量
104.4 KDa
SMILES Code
NONE
别名
重组生物素化人HGF R蛋白(C-6His-Avi, HEK293)
;Biotinylated Human HGF R (C-6His-Avi, HEK293); Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met; MET
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Biotinylated Human HGF R (C-6His-Avi, HEK293)
|Biotinylated Human HGF R (C-6His-Avi, HEK293)
| 重组生物素化人HGF R蛋白(C-6His-Avi, HEK293)
| Hepatocyte growth factor receptor
| HGF receptor
| HGF/SF receptor
| Proto-oncogene c-Met
| Scatter factor receptor
| SF receptor
| Tyrosine-protein kinase Met
| MET
| N/A
| Enzymes & Regulators
| HGF & Receptors
| Receptor Proteins
| c-Met/HGFR/Recombinant Protein
| Biotinylated Human HGF R (C-6His-Avi, HEK293) 纯度/质量文件
| Biotinylated Human HGF R (C-6His-Avi, HEK293) 生物活性
| Biotinylated Human HGF R (C-6His-Avi, HEK293) 技术信息
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