Bevirimat is an anti-HIV drug derived from a betulinic acid-like compound, and is believed to inhibit HIV by a so-called maturation inhibition mechanism.
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Bevirimat is an anti-HIV drug derived from a betulinic acid-like compound, and is believed to inhibit HIV by a so-called maturation inhibition mechanism.
Bevirimat/贝韦立马 细胞实验
Cell Line
Concentration
Treated Time
Description
References
TZM-bl cells
2 µM
No inhibitory activity observed
J Med Chem. 2016 Oct 13;59(19):9262-9268
CEM-T4 cells
0.02-10 μM
7 days
Evaluation of anti-HIV-1 activity, results showed IC50 of Bevirimat was 0.03 μM.
Biomolecules. 2020 Aug 5;10(8):1148
MT4 cells
0.076 μM (IC50)
4 days
Evaluate the inhibitory effect of Bevirimat on wild-type HIV-1 NL4-3, results showed IC50 of 0.076 μM
J Med Chem. 2013 Mar 14;56(5):2029-37
HeLa cells
1.0 or 2.0 μg/ml
2 h
Evaluation of the effect of PA-457-resistant mutations on CA-SP1 processing, showing marked accumulation of CA-SP1 in both cell and virion fractions in PA-457-treated WT pNL4-3-transfected cells, while no accumulation was observed for mutants CA-H226Y, SP1-A1V, SP1-A3T, or SP1-A3V in the presence of PA-457.
J Virol. 2006 Nov;80(22):10957-71
Jurkat T cells
50 ng/ml
Selection of PA-457-resistant HIV-1 isolates by serial passage of Jurkat T cells transfected with WT HIV-1 pNL4-3 at 50 ng/ml PA-457, monitoring virus replication by RT activity to confirm acquisition of PA-457 resistance.
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