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/ 糖皮质激素受体 / Betamethasone dipropionate/二丙酸倍他米松

Betamethasone dipropionate/二丙酸倍他米松 {[allProObj[0].p_purity_real_show]}

货号：A624424 同义名： 17,21-二丙酸倍他米松酯 / Betamethasone 17,21-dipropionate; SCH 11460

Betamethasone dipropionate 是倍氯米松的二丙酸酯形式，具有抗炎作用。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Betamethasone dipropionate/二丙酸倍他米松 化学结构 CAS号：5593-20-4
Betamethasone dipropionate/二丙酸倍他米松 化学结构
CAS号：5593-20-4
Betamethasone dipropionate/二丙酸倍他米松 3D分子结构
CAS号：5593-20-4
Betamethasone dipropionate/二丙酸倍他米松 化学结构 CAS号：5593-20-4
Betamethasone dipropionate/二丙酸倍他米松 3D分子结构 CAS号：5593-20-4
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Betamethasone dipropionate/二丙酸倍他米松 纯度/质量文件 产品仅供科研

货号：A624424 标准纯度： {[allProObj[0].p_purity_real_show]}
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Betamethasone dipropionate/二丙酸倍他米松 生物活性

描述 Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.

Betamethasone dipropionate/二丙酸倍他米松 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Fetal sheep Fetal sheep model Intravenous infusion 3.3 µg/kg/h Continuous for 48 hours To study the effects of betamethasone on fetal cerebral blood flow, results showed a 40% decrease in CBF after 24 hours, with recovery after 48 hours. J Physiol. 2005 Apr 15;564(Pt 2):575-88
Guinea pigs Pregnant guinea pig model Subcutaneous injection 1 mg/kg Two doses, 24 hours apart To investigate the effects of antenatal corticosteroid exposure on DNA methylation patterns in the blood of newborn guinea pigs, identifying 1677 differentially methylated CpG sites (DMCs), of which 956 sites were hypermethylated and 721 sites were hypomethylated. Transl Psychiatry. 2024 Nov 7;14(1):465
Mice Chronic maternal hypoxia model Subcutaneous injection 0.1 mg Single injection, followed by ultrasound imaging after 4 hours To investigate the effects of betamethasone on feto-placental vascular resistance in a mouse model of chronic hypoxia, showing that female fetuses exhibited increased UA diameter and blood flow and decreased reflection coefficient post-treatment, while males showed no significant changes. Am J Obstet Gynecol MFM. 2021 Jan;3(1):100251
Guinea pigs Pregnant guinea pigs Subcutaneous injection 1 mg/kg Injected on gestational days 40, 41, 50, 51, 60, and 61 To investigate the effects of prenatal exposure to synthetic glucocorticoids on hippocampal long-term potentiation (LTP) in offspring. Results showed that prenatal sGC treatment had no effect on LTP under basal conditions; however, in the presence of high cortisol (10 μM), LTP was not inhibited in female offspring prenatally exposed to betamethasone, while it was suppressed in all other groups. J Physiol. 2007 Jun 15;581(Pt 3):1033-42

Betamethasone dipropionate/二丙酸倍他米松 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03165825 Cervical Radiculopathy Phase 4 Withdrawn(funding) October 2019 -
NCT03196817 Carpal Tunnel Syndrome Phase 4 Active, not recruiting December 2017 Brazil ... 展开 >> Jesus Queiroz junior São Paulo, Brazil, 03325000 收起 <<
NCT02978976 Neonatal Respiratory Distress Phase 4 Recruiting May 2018 Egypt ... 展开 >> 11562 Recruiting Cairo, Egypt, 11562 Contact: Ahmed M KameL, M.D    01120022332    dr.ahmed.m.kamel@gmail.com 收起 <<

Betamethasone dipropionate/二丙酸倍他米松 参考文献

[1]Yan R, Jiang S, et al. Topical calcipotriol/betamethasone dipropionate for psoriasis vulgaris: A systematic review. Indian J Dermatol Venereol Leprol. 2016 Mar-Apr;82(2):135-44.

[2]Leonardi C, Bagel J, et al. Efficacy and Safety of Calcipotriene Plus Betamethasone Dipropionate Aerosol Foam in Patients With Psoriasis Vulgaris--a Randomized Phase III Study (PSO-FAST). J Drugs Dermatol. 2015 Dec;14(12):1468-77.

Betamethasone dipropionate/二丙酸倍他米松 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.98mL

0.40mL

0.20mL

9.91mL

1.98mL

0.99mL

19.82mL

3.96mL

1.98mL

Betamethasone dipropionate/二丙酸倍他米松 技术信息

CAS号5593-20-4
分子式C28H37FO7
分子量 504.59
SMILES Code CCC(O[C@]1(C(COC(CC)=O)=O)[C@@H](C)C[C@@]2([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)=O)=O
MDL No. MFCD00133140
别名 17,21-二丙酸倍他米松酯 ;Betamethasone 17,21-dipropionate; SCH 11460; Luxiq; Diprosone; Diprolene AF; Diprolene; BetaVal; Alphatrex
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, room temperature
溶解方案

DMSO: 105 mg/mL(208.09 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二

Tags: Betamethasone | 5593-20-4 | Betamethasone 17,21-dipropionate | Glucocorticoid Receptor | Glucocorticoid Receptor Modulator | Immunology/Inflammation | Vitamin D Related/Nuclear Receptor | Glucocorticoid Receptor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Betamethasone dipropionate/二丙酸倍他米松 纯度/质量文件 | Betamethasone dipropionate/二丙酸倍他米松 生物活性 | Betamethasone dipropionate/二丙酸倍他米松 临床数据 | Betamethasone dipropionate/二丙酸倍他米松 参考文献 | Betamethasone dipropionate/二丙酸倍他米松 实验方案 | Betamethasone dipropionate/二丙酸倍他米松 技术信息

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