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/ Benazepril HCl/盐酸贝那普利

Benazepril HCl/盐酸贝那普利 {[allProObj[0].p_purity_real_show]}

货号：A430288 同义名： CGS14824A; Benazepril (hydrochloride)

Benazepril HCl 是一种血管紧张素转化酶（ACE）抑制剂，常用于高血压的研究。

Benazepril HCl/盐酸贝那普利 化学结构 CAS号：86541-74-4
Benazepril HCl/盐酸贝那普利 化学结构
CAS号：86541-74-4
Benazepril HCl/盐酸贝那普利 3D分子结构
CAS号：86541-74-4
Benazepril HCl/盐酸贝那普利 化学结构 CAS号：86541-74-4
Benazepril HCl/盐酸贝那普利 3D分子结构 CAS号：86541-74-4
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Benazepril HCl/盐酸贝那普利 纯度/质量文件 产品仅供科研

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Benazepril HCl/盐酸贝那普利 生物活性

描述 Benazepril hydrochloride, an angiotensin converting enzyme (ACE) inhibitor, which is a medication used to treat high blood pressure. Benazepril decreases ILK(Integrin-linked kinase) and α-SMA (Smooth muscle α-actin) expression by affecting the interactions between Ang II(Angiotensin II) and TGF-β1(Transforming growth factor-β1)[3]. Benazepril hydrochloride improves DN (diabetic nephropathy) and decreases proteinuria by decreasing ANGPTL-4 expression[4]. Combination therapy with amlodipine/benazepril is more effective in BP (blood pressure) lowering than monotherapy with the component drugs[5].

Benazepril HCl/盐酸贝那普利 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Wistar rats Diabetic nephropathy model Intra-gastric intubation 10 mg/kg Once daily for 4 weeks To compare the effects of ACE2 overexpression and ACE inhibition (Benazepril) on diabetic nephropathy. Results showed that Benazepril treatment significantly reduced systolic blood pressure, urinary albumin excretion, creatinine clearance, and glomerulosclerosis index, with effects similar to ACE2 overexpression. Mol Med. 2011 Jan-Feb;17(1-2):59-69
C57/BL6 mice Type 2 diabetic nephropathy model Intragastrically 10 mg/kg Once daily for 8 weeks Benazepril alleviated the inflammation and fibrosis process in diabetic nephropathy mice, but the effect was not as significant as the IGF-1R inhibitor Drug Des Devel Ther. 2018 Sep 11;12:2887-2896
Adult male Sprague-Dawley rats Streptozotocin-induced diabetic model Oral 10 mg/kg Once daily for 7 days To investigate the effect of Benazepril on intracellular angiotensin II (iAng II) synthesis in cardiac myocytes of diabetic rats. Results showed that Benazepril did not inhibit diabetes-induced elevation of iAng II levels but partially inhibited diabetes-induced superoxide production and cardiac fibrosis. Diabetes. 2008 Dec;57(12):3297-306
Rats 5/6 nephrectomy model Gavage 5 mg/kg Once daily for 4 weeks To evaluate the inhibitory effect of Benazepril on peritoneal fibrosis. Results showed that the peritoneal thickness and fibrosis area in the Benazepril group were significantly lower than those in the model group but higher than those in the control group. Front Pharmacol. 2021 Oct 1;12:628671

Benazepril HCl/盐酸贝那普利 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00000620 Atherosclerosis ... 展开 >> Cardiovascular Diseases Hypercholesterolemia Hypertension Diabetes Mellitus, Type 2 Diabetes Mellitus Coronary Disease 收起 << Phase 3 Completed - United States, Minnesota ... 展开 >> Minneapolis Medical Research Foundation Minneapolis, Minnesota, United States, 55404 United States, New York Columbia University New York, New York, United States, 10027 United States, North Carolina Wake Forest University Winston-Salem, North Carolina, United States, 27106 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 United States, Tennessee Veterans Affairs Memphis, Tennessee, United States, 38104 United States, Washington University of Washington Seattle, Washington, United States, 98195 Canada, Ontario McMaster University Hamilton, Ontario, Canada 收起 <<
NCT01076205 - Completed - -
NCT01669434 - Completed - -

Benazepril HCl/盐酸贝那普利 参考文献

[1]Yamamoto S, Takemori E, et al. General pharmacology of the novel angiotensin converting enzyme inhibitor benazepril hydrochloride. Effects on central nervous and sensory systems and other functions. Arzneimittelforschung. 1991 Jun;41(6):602-7.

[2]Yamamoto S, Takemori E, et al. General pharmacology of the novel angiotensin converting enzyme inhibitor benazepril hydrochloride. Effects on cardiovascular, visceral and renal functions and on hemodynamics. Arzneimittelforschung. 1991 Sep;41(9):913-23.

[3]Niu H, Nie L, Liu M, Chi Y, Zhang T, Li Y. Benazepril affects integrin-linked kinase and smooth muscle α-actin expression in diabetic rat glomerulus and cultured mesangial cells. BMC Nephrol. 2014 Aug 20;15:135. doi: 10.1186/1471-2369-15-135. PMID: 25142208; PMCID: PMC4151867.

[4]Xue L, Feng X, Wang C, Zhang X, Sun W, Yu K. Benazepril hydrochloride improves diabetic nephropathy and decreases proteinuria by decreasing ANGPTL-4 expression. BMC Nephrol. 2017 Oct 4;18(1):307. doi: 10.1186/s12882-017-0724-1. PMID: 28978304; PMCID: PMC5628429.

[5]Chrysant SG. Blood pressure effects of high-dose amlodipine-benazepril combination in Black and White hypertensive patients not controlled on monotherapy. Drugs R D. 2012 Jun 1;12(2):57-64. doi: 10.2165/11633430-000000000-00000. PMID: 22571394; PMCID: PMC3586097.

Benazepril HCl/盐酸贝那普利 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.85mL

2.17mL

1.08mL

21.69mL

4.34mL

2.17mL

Benazepril HCl/盐酸贝那普利 技术信息

CAS号86541-74-4
分子式C24H29ClN2O5
分子量 460.95
SMILES Code O=C(CN1C([C@H](CCC2=C1C=CC=C2)N[C@@H](CCC3=CC=CC=C3)C(OCC)=O)=O)O.[H]Cl
MDL No. MFCD00895734
别名 CGS14824A; Benazepril (hydrochloride); CGS 14824A HCl; Benazepril hydrochloride
运输蓝冰
InChI Key VPSRQEHTHIMDQM-FKLPMGAJSA-N
Pubchem ID 5362123
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, inert atmosphere, room temperature
溶解方案

DMSO: 105 mg/mL(227.79 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 10 mg/mL(21.69 mM)，配合低频超声助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三
配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一

Tags: Benazepril | 86541-74-4 | CGS14824A | Angiotensin-converting Enzyme (ACE) | ACE Inhibitor | Metabolic Enzyme/Protease | Angiotensin-converting Enzyme (ACE) | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Benazepril HCl/盐酸贝那普利 纯度/质量文件 | Benazepril HCl/盐酸贝那普利 生物活性 | Benazepril HCl/盐酸贝那普利 临床数据 | Benazepril HCl/盐酸贝那普利 参考文献 | Benazepril HCl/盐酸贝那普利 实验方案 | Benazepril HCl/盐酸贝那普利 技术信息

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