Baccatin III 是一种从 Taxus chinensis 树皮中分离并纯化的天然产物，也是一种紫杉醇的前体，紫杉醇具有抗癌活性。
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HazMat fee for 500 gram (Estimated)
Excepted Quantity
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Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
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Accessible (Haz class 3, 4, 5 or 8), International
Baccatin III is a precursor to the anti-cancer drug paclitaxel, it's a natural product isolated and purified from the barks of Taxus chinensis. Baccatin III, which is the precursor for the semisynthesis of paclitaxel, exerts anti-tumor immunomodulatory activity in very low doses (0.05-0.5mg/kg). Oral administration of baccatin III significantly reduced the growth of tumors induced by engrafting BALB/c mice with either 4 T1 mammary carcinoma or CT26 colon cancer cells. Baccatin III (0.5mg/kg) did not exert anti-tumor activity in athymic nude mice. Baccatin III decreased the accumulation of MDSCs (Myeloid-derived suppressor cells) in the spleens of the tumor-bearing mice[3]. Baccatin III inhibited cell proliferation of a number of cancer cell lines with IC50 ranging from 2 to 5 μM for fungal baccatin III. It also induced apoptosis in JR4-Jurkat cells with a possible involvement of anti-apoptotic Bcl2 and loss in mitochondrial membrane potential, and was unaffected by inhibitors of caspase-9,-2 or -3 but was prevented in presence of caspase-10 inhibitor. DNA fragmentation was also observed in cells treated with baccatin III[4].
Baccatin III/巴卡亭 Ⅲ 细胞实验
Cell Line
Concentration
Treated Time
Description
References
T47D cells
2 μM
48 h
Inhibited cell proliferation with IC50 of 2 μM
Cancer Cell Int. 2013 Oct 23;13(1):105
HepG2 cells
3 μM
48 h
Inhibited cell proliferation with IC50 of 3 μM
Cancer Cell Int. 2013 Oct 23;13(1):105
HeLa cells
3 μM
12 h
Induced apoptosis, manifested as chromatin aggregation and nuclear condensation
Cancer Cell Int. 2013 Oct 23;13(1):105
guinea-pig ileal smooth muscle cells
100 μM
3.9 ± 0.6 h
To evaluate the effect of Baccatin III on voltage-gated Ca2+ channel current (IBa), results showed no significant effect.
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