BTYNB
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货号：A1464578
同义名：
BTYNB IMP1 Inhibitor; MDK6620
BTYNB是一种强效且选择性的 IMP1 抑制剂，通过抑制 IMP1 与 c-Myc mRNA 的结合，IC50 为 5 μM。它下调了 IMP1 调节的多个 mRNA 转录本，从而下调了 c-Myc mRNA 和蛋白质，包括 c-Myc mRNA、β-TrCP1 mRNA 和 eEF2 mRNA，同时减少了 NF-κB 的激活。
BTYNB 化学结构
BTYNB 3D分子结构
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BTYNB 纯度/质量文件 产品仅供科研
货号：A1464578
标准纯度：
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产品说明书
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BTYNB 质控信息
BTYNB 生物活性
描述
BTYNB is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA (IC50=5 μM). BTYNB exhibits selectivity and effectiveness against IMP1-postive cancer cell lines. BTYNB elicits a robust dose-dependent inhibition of cell proliferation in IMP1-positive cells with IC50 values of 2.3 μM, 3.6 μM, and 4.5 μM in ES-2, IGROV-1, and SK-MEL2 cells, respectively. Pretreatment with 10μM BTYNB for 72 hours enhances the degradation rate of c-Myc mRNA in SK-MEL2 cells[2] [3]
BTYNB 参考文献
[1] Mahapatra L, Andruska N, Mao C, Le J, Shapiro DJ. A Novel IMP1 Inhibitor, BTYNB, Targets c-Myc and Inhibits Melanoma and Ovarian Cancer Cell Proliferation. Transl Oncol. 2017 Oct;10(5):818-827. doi: 10.1016/j.tranon.2017.07.008. Epub 2017 Aug 29. PMID: 28846937; PMCID: PMC5576976.
[2] Mahapatra L, Andruska N, Mao C, Le J, Shapiro DJ. A Novel IMP1 Inhibitor, BTYNB, Targets c-Myc and Inhibits Melanoma and Ovarian Cancer Cell Proliferation. Transl Oncol. 2017 Oct;10(5):818-827.
[3] Müller S, Bley N, Busch B, Glaß M, Lederer M, Misiak C, Fuchs T, Wedler A, Haase J, Bertoldo JB, Michl P, Hüttelmaier S. The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer. Nucleic Acids Res. 2020 Sep 4;48(15):8576-8590.
BTYNB 实验方案
计算器
摩尔计算器
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1mg
5mg
10mg
1 mM
5 mM
10 mM
3.23mL
0.65mL
0.32mL
16.17mL
3.23mL
1.62mL
32.34mL
6.47mL
3.23mL
BTYNB 技术信息
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