BSO treatment did not significantly improve the survival of AML-bearing mice
Cell Metab. 2020 Sep 1;32(3):391-403.e6
Mice
C57BL/6 mice
Intraperitoneal injection
100 mg/kg
Single dose, 2 hours duration
BSO treatment increased mitochondrial content in LSK and HSC populations, mimicking LPS and S. typhimurium-induced ROS elevation.
Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24610-24619
Mice
GSH-depleted model
Intraperitoneal injection
650 mg/kg
Single dose, lasting 24 hours
To evaluate the effect of BSO on psoralen and isopsoralen-induced hepatotoxicity, results showed that BSO significantly enhanced the hepatotoxicity of psoralen
Molecules. 2017 Sep 4;22(9):1451
BALB/c nu/nu athymic mice
HCC827 cell-derived xenograft model
Intraperitoneal injection
450 mg/kg
Every 2 days, until the end of the experiments
Investigated the effect of BSO on ALDH1A1-induced erlotinib resistance, finding that BSO could reverse ALDH1A1-induced erlotinib resistance.
Theranostics. 2019 Sep 23;9(24):7122-7139
Mice
FVB and MT overexpression transgenic mice
Drinking water
30 mM
2 weeks
To evaluate the effects of BSO on cardiac function, oxidative stress, ER stress, and myocardial ultrastructure, results showed that BSO significantly reduced cardiac function, increased oxidative stress and ER stress, and caused changes in myocardial ultrastructure, while MT overexpression reversed these effects.
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