There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
The high-density lipoprotein (HDL) receptor, scavenger receptor, class B, type I (SR-BI), plays an important role in controlling the structure and metabolism of HDL. BLT-1, a thiosemicarbazone copper chelator, is a selective scavenger receptor B, type 1 (SR-BI) inhibitor that inhibits the transfer of lipids between HDL and cells mediated by SR-BI. In ldlA[mSR-BI] cells, BLT-1 had IC50s of 60 and 110 nM for cellular DiI-HDL and [3H]CE-HDL uptake[2]. BLT-1 inhibited SR-BI-dependent selective uptake of [3H]CE from [3H]CE-HDL by mSR-BI-t1-containing liposomes in cells and liposomes with IC50s of 0.057 and 0.098 µM, respectively[3].
BLT-1 细胞实验
Cell Line
Concentration
Treated Time
Description
References
PCNSL cell lines (HKBML, TK)
10 µM
24 hours
Inhibited lymphoma cell proliferation
Cancer Sci. 2022 Jun;113(6):2129-2143.
COS cells
1 µM
1 hour
Assess the effect of BLT-1 on HDL binding and lipid uptake activities of SR-BI mutants (C251S, C384S, C251/384S), showing complete resistance of C384S mutant to BLT-1
Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12243-8.
LdlA[SR-BI] cells
1 µM
1 hour
Evaluate the inhibitory effect of BLT-1 on SR-BI-mediated DiI-HDL lipid uptake, showing that BLT-1 inhibition of SR-BI is essentially irreversible
Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12243-8.
Human monocyte-derived macrophages (HMDMs)
10 µM
1 hour
BLT-1 treatment increased miR-223-3p export to HDL in HMDMs
Atherosclerosis. 2019 Jul;286:20-29.
Polymorphonuclear neutrophils (PMNs)
10 µM
1 hour
Chemical inhibition of cholesterol flux by BLT-1 inhibited HDL-induced pri-mir-223 expression in PMNs
Atherosclerosis. 2019 Jul;286:20-29.
COS7 cells
10 µM
1 hour
BLT-1 inhibits SR-B1-mediated HDL-CE uptake but does not affect fatty acid uptake
Inhibited lymphoma cell proliferation and induced apoptosis
Cancer Sci. 2022 Jun;113(6):2129-2143.
HCMEC/D3 cells
1 µM
4 hours
To evaluate the effect of BLT-1 on HDL-mediated protection of BBB integrity, showing that 1 µM BLT-1 partially counteracted the protective effects of HDLs
To study the effect of BLT-1 on the proliferation of E. bovis and E. arloingi, results showed that BLT-1 significantly inhibited the replication of these parasites.
Microorganisms. 2021 Nov 17;9(11):2372.
African green monkey kidney epithelial cells (MARC 145)
0.25-2 µM
48 hours
To study the effect of BLT-1 on the proliferation of T. gondii, N. caninum, and B. besnoiti, results showed that BLT-1 significantly inhibited the replication of these parasites.
Microorganisms. 2021 Nov 17;9(11):2372.
BLT-1 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
SCID mice
Subcutaneous ED cell lymphoma model
Intraperitoneal injection
20 mg/kg
Administered daily from day 14 to day 32
Significantly suppressed tumor development and prolonged survival
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