There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
BD-1047 Dihydrobromide is a selective functional antagonist of sigma-1 receptor, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia. BD 1047 did not decrease amphetamine-induced hyperactivity in mice in a statistically significant manner. Likewise, it did not modify the hyperactivity induced by NMDA receptor antagonists, phencyclidine, memantine or dizocilpine. On the other hand, BD 1047 (1-10 mg/kg; i.p.) attenuated apomorphine-induced climbing in mice and phencyclidine-induced head twitches in rats, like rimcazole and panamesine did[3]. BD-1047 Dihydrobromide prevents that Cutamesine reduces the cell death rate induced by light exposure in murine photoreceptor-derived 661w cells. BD-1047 attenuates that Cutamesine reduces the mitochondrial damage and the elevated level of caspase 3/7 activity[4]. Intrathecal (i.t.) pretreatment with the selective sigma-1 receptor antagonist, BD-1047 dihydrobromide (10-100 nmol) dose dependently reduced formalin-induced pain behaviors in second phase, but not first phase, of the formalin test. I.t. injection of BD-1047 also reduced formalin-evoked Fos expression and pNR1 at the protein kinase C-dependent site, serine-896 (Ser896) and the protein kinase A-dependent site, serine-897 (Ser897) in spinal dorsal horn.i.t[5].
BD-1047 2HBr 细胞实验
Cell Line
Concentration
Treated Time
Description
References
HT22 cells
1 μM
1 hour
To verify the antioxidative effect of YL-0919 via σ-1R
Neural Regen Res. 2025 Aug 1;20(8):2325-2336.
BD-1047 2HBr 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
ICR mice
Formalin-induced pain model
Intrathecal injection
10–100 nmol
Single administration, observed for 30 minutes
BD-1047 dose-dependently reduced formalin-induced pain behaviors in the second phase but not the first phase. Additionally, BD-1047 reduced formalin-evoked Fos expression and pNR1 (Ser896 and Ser897) expression in the spinal dorsal horn.
Br J Pharmacol. 2006 Jun;148(4):490-8
ICR mice
Chronic constriction injury (CCI) model
Intrathecal injection
100 nmol
Twice daily on post-operative days 0–3
BD-1047 significantly attenuated CCI-induced mechanical allodynia (MA) but not thermal hyperalgesia (TH). BD-1047 also reduced CCI-induced astrocyte activation and p38 MAPK phosphorylation.
Br J Pharmacol. 2014 Dec;171(24):5881-97
Guinea pigs
Citric-acid-induced cough model
Intraperitoneal injection
1–5mg/kg
Single dose, 30 minutes pretreatment
BD-1047 reversed the inhibition of cough elicited by SKF-10,047, indicating its role as a sigma-1 receptor antagonist
Br J Pharmacol. 2004 Jan;141(2):233-40
Rats
KA-induced seizure model
Intraperitoneal injection
1 or 2 mg/kg
Single administration, 15 minutes before pretreatment
BD-1047 significantly counteracted the anticonvulsant effects of dextromethorphan or dimemorfan on KA-induced seizure behaviors, suggesting that its action is partly related to σ1 receptor activation.
Br J Pharmacol. 2005 Apr;144(7):908-18
C57BL/6J mice
Traumatic brain injury model
Intragastric gavage
4 mg/kg
Once daily for 3 days
To verify the neuroprotective effect of YL-0919 via σ-1R
Neural Regen Res. 2025 Aug 1;20(8):2325-2336.
Mice
Mechanical allodynia model
Intrathecal injection
10, 30, 100 nmol
Single injection
BD-1047 significantly reduced DHEAS-induced mechanical allodynia, indicating that sigma-1 receptors play an important role in DHEAS-induced allodynia.
Br J Pharmacol. 2009 Jun;157(4):666-73
ICR mice
NMDA-induced pain model
Intrathecal injection
100 nmol
Single dose, observed for 60 minutes
BD-1047 significantly reduced the increased pNR1 expression induced by Sig-1R agonists PRE-084 or carbetapentane and reversed NMDA-induced pain behaviors
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