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首页 / 抑制剂/激动剂 / 细胞周期 / BUB / BAY-1816032

BAY-1816032 {[allProObj[0].p_purity_real_show]}

货号：A1176577

BAY-1816032是一种强效的BUB1激酶抑制剂，IC50为7 nM。

BAY-1816032 化学结构 CAS号：1891087-61-8
BAY-1816032 化学结构
CAS号：1891087-61-8
BAY-1816032 3D分子结构
CAS号：1891087-61-8
BAY-1816032 化学结构 CAS号：1891087-61-8
BAY-1816032 3D分子结构 CAS号：1891087-61-8
规格 价格 会员价 库存 数量
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BAY-1816032 纯度/质量文件 产品仅供科研

货号：A1176577 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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BAY-1816032 细胞实验

Cell Line
Concentration Treated Time Description References
MCF10A cells 1 nM to 10 μM 72 h To evaluate the effect of BAY-1816032 on normal mammary epithelial cell proliferation, IC50 was 18 μM. J Exp Clin Cancer Res. 2024 Jun 11;43(1):163.
T-47D cells 1 nM to 10 μM 72 h To evaluate the effect of BAY-1816032 on Luminal A subtype breast cancer cell proliferation, IC50 was 3.9 μM. J Exp Clin Cancer Res. 2024 Jun 11;43(1):163.
BT-549 cells 1 nM to 10 μM 72 h To evaluate the effect of BAY-1816032 on TNBC cell proliferation, IC50 was 1.59 μM. J Exp Clin Cancer Res. 2024 Jun 11;43(1):163.
MDA-MB-468 cells 1 nM to 10 μM 72 h To evaluate the effect of BAY-1816032 on TNBC cell proliferation, IC50 was 2.59 μM. J Exp Clin Cancer Res. 2024 Jun 11;43(1):163.
MDA-MB-231 cells 1 nM to 10 μM 72 h To evaluate the effect of BAY-1816032 on TNBC cell proliferation, IC50 was 2.10 μM. J Exp Clin Cancer Res. 2024 Jun 11;43(1):163.
SUM159 cells 1 nM to 10 μM 72 h To evaluate the effect of BAY-1816032 on TNBC cell proliferation, IC50 was 2.90 μM. J Exp Clin Cancer Res. 2024 Jun 11;43(1):163.
HCC1937 cells 250 nM 72 h To evaluate the sensitization effect of BAY1816032 to olaparib in BRCA-mutant TNBC cell line. Results showed that BAY1816032 significantly enhanced the cytotoxicity of olaparib at lower concentrations. Biomolecules. 2024 May 25;14(6):625.
MDA-MB-231 cells 1 µM 72 h To evaluate the cytotoxic effects of BAY1816032 in combination with olaparib, cisplatin, and paclitaxel. Results showed that BAY1816032 significantly enhanced the cytotoxicity of these drugs in TNBC cell lines. Biomolecules. 2024 May 25;14(6):625.
SUM159 cells 1 µM 72 h To evaluate the cytotoxic effects of BAY1816032 in combination with olaparib, cisplatin, and paclitaxel. Results showed that BAY1816032 significantly enhanced the cytotoxicity of these drugs in TNBC cell lines. Biomolecules. 2024 May 25;14(6):625.
TPC-1 cells 0-50 μM 48 h Determination of IC50 value, BAY-1816032 significantly reduced cell viability J Cell Mol Med. 2024 Apr;28(7):e18182.
8505C cells 0-50 μM 48 h Determination of IC50 value, BAY-1816032 significantly reduced cell viability J Cell Mol Med. 2024 Apr;28(7):e18182.
bone marrow-derived macrophages (BMMs) 100 nM or 1 μM BAY1816032 significantly increased osteoclastogenesis in BMMs J Bone Miner Res. 2024 Apr 19;39(3):341-356.

BAY-1816032 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
CB17/SCID mice SUM159 mammary fat pad xenograft model Oral 25 mg/kg Twice daily for four weeks To evaluate the effect of BAY-1816032 combined with radiotherapy on SUM159 xenograft tumor growth, results showed that the combination treatment significantly reduced tumor volume and prolonged animal survival. J Exp Clin Cancer Res. 2024 Jun 11;43(1):163.
Nude mice ATC xenograft model Oral 100 mg/kg Once daily for 24 days Evaluation of anti-tumor activity and safety of BAY-1816032, results showed significant reduction in tumor volume and weight J Cell Mol Med. 2024 Apr;28(7):e18182.

BAY-1816032 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.87mL

0.37mL

0.19mL

9.35mL

1.87mL

0.94mL

18.71mL

3.74mL

1.87mL

BAY-1816032 技术信息

CAS号1891087-61-8
分子式C27H24F2N6O4
分子量 534.51
SMILES Code FC1=C(C(F)=CC(OCCO)=C1)CN2C3=CC=CC=C3C(C4=NC=C(OC)C(NC5=CC=NC=C5OC)=N4)=N2
MDL No. MFCD31657337
别名
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C
溶解方案

DMSO: 25 mg/mL(46.77 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三

Tags: BAY-1816032 | 1891087-61-8 | BAY1816032 | BAY 1816032 | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | BAY-1816032 纯度/质量文件 | BAY-1816032 实验方案 | BAY-1816032 技术信息

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