Atractylodin is an active component of the essential oil contained in the rhizomes of Atractylodes lancea and A.
Atractylodin/苍术素 细胞实验
Cell Line
Concentration
Treated Time
Description
References
HCT116 cells
50 μM
24 h
Determine the non-cytotoxic concentration of Atractylodin
Int J Mol Sci. 2023 Jan 2;24(1):802
HCT116 cells
50 μM
1 hour
Investigate the inhibitory effect of Atractylodin on TNF-α-induced NF-κB p65 phosphorylation
Int J Mol Sci. 2023 Jan 2;24(1):802
rat dorsal root ganglion neurons
5 µM
30 s
ATR induced a long-lasting calcium response, persisting for over 1 h
Int J Mol Sci. 2021 Mar 31;22(7):3614
hTRPA1-transfected HEK293 cells
10 µM
1 min
ATR induced long-lasting TRPA1 channel activation, persisting beyond 3 min after washout
Int J Mol Sci. 2021 Mar 31;22(7):3614
A549 cells
0-100 μM
24 h
To evaluate the effect of Atractylodin on TGF-β1-induced EMT in A549 cells, results showed that Atractylodin suppressed EMT-related protein expressions.
Int J Mol Sci. 2021 Oct 15;22(20):11152
RAW264.7 cells
10, 20, 40 μM
24 h
To investigate the inhibitory effect of Atractylodin on LPS-induced inflammatory response in macrophages. Results showed that Atractylodin significantly inhibited the mRNA expression of TNF-α, IL-1β, IL-6, and iNOS, and downregulated the phosphorylation levels of MAPK pathway proteins.
Front Pharmacol. 2021 Jul 15;12:665376
HCC827 lung cancer cells
61.05 μM
24 h
Cell viability was detected by the Cell Counting Kit-8 assay, and results showed that ATR could significantly inhibit the proliferation of HCC827 cells
Molecules. 2022 May 5;27(9):2946
NCI-H460 lung cancer cells
63.27 μM
24 h
Cell viability was detected by the Cell Counting Kit-8 assay, and results showed that ATR could significantly inhibit the proliferation of NCI-H460 cells
Molecules. 2022 May 5;27(9):2946
NCI-H23 lung cancer cells
76.88 μM
24 h
Cell viability was detected by the Cell Counting Kit-8 assay, and results showed that ATR could significantly inhibit the proliferation of NCI-H23 cells
Molecules. 2022 May 5;27(9):2946
A549 lung cancer cells
37.92 μM
24 h
Cell viability was detected by the Cell Counting Kit-8 assay, and results showed that ATR could significantly inhibit the proliferation of A549 cells
Molecules. 2022 May 5;27(9):2946
Atractylodin/苍术素 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Male SD rats
LPS-induced acute lung injury model
Gavage
10 mg/kg, 40 mg/kg
Once daily for 7 days
To evaluate the therapeutic effects of ATL on acute lung injury. Results showed that ATL significantly reduced the lung wet/dry ratio, improved pathological changes, and lowered the expression levels of inflammatory factors TNF-α, IL-1β, IL-6, COX-2, and iNOS, as well as reduced neutrophil and macrophage aggregation.
iScience. 2024 Aug 31;27(10):110751
C57BL/6 mice
DSS-induced colitis model
Intraperitoneal injection
40 mg/kg
Once daily for 14 days
Investigate the ameliorative effect of Atractylodin on colitis symptoms
To evaluate the therapeutic effect of Atractylodin on bleomycin-induced pulmonary fibrosis, results showed that Atractylodin attenuated pulmonary fibrosis and reduced collagen deposition.
Int J Mol Sci. 2021 Oct 15;22(20):11152
Mice
Klotho-deficient and SAMP8 mice
Oral
1 mg/kg
Daily administration
Atractylodin significantly prolonged the survival of klotho-deficient mice, ameliorated several age-related diseases, and reduced microglial activation in the brain
Mol Psychiatry. 2016 Nov;21(11):1613-1623
Wistar rats
AH-130 ascites hepatoma tumor-bearing rats
Oral
1 mg/kg
Daily administration
Atractylodin significantly prolonged the median survival time of tumor-bearing rats.
Transl Psychiatry. 2011 Jul 26;1(7):e23
BALB/c mice
DSS-induced ulcerative colitis model
Intraperitoneal injection
10 or 20 mg/kg
Once daily for 7 days
To evaluate the therapeutic effects of Atractylodin on DSS-induced ulcerative colitis. Results showed that Atractylodin significantly improved symptoms such as weight loss, disease activity index score, and colon length shortening, and inhibited macrophage activation and inflammatory cytokine production in colon tissues.
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