Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
酶学
/
酶抑制剂
蛋白酶
/
蛋白酶抑制剂
丝氨酸
/ Aprotinin/抑肽酶

Aprotinin/抑肽酶 {[allProObj[0].p_purity_real_show]}

货号：A328348 同义名： 抑肽酶 / Bovine Pancreatic Trypsin Inhibitor; BPTI

Aprotinin是一种丝氨酸蛋白酶抑制剂，能抑制胰蛋白酶和胰凝乳蛋白酶，Ki 值分别为 0.06 pM 和 9 nM，用于减少术中失血和输血需求。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Aprotinin/抑肽酶 化学结构 CAS号：9087-70-1
Aprotinin/抑肽酶 化学结构
CAS号：9087-70-1
Aprotinin/抑肽酶 3D分子结构
CAS号：9087-70-1
Aprotinin/抑肽酶 化学结构 CAS号：9087-70-1
Aprotinin/抑肽酶 3D分子结构 CAS号：9087-70-1
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} 		{[ getRatePriceInt(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate,item.mem_isinteger) ]} 现货 1周 咨询 - +
购物车0 收藏 询单

Aprotinin/抑肽酶 纯度/质量文件 产品仅供科研

货号：A328348 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Mater., 2025, 24, 1116-1125. Ambeed. [ A141030 , A131652 ]
更多 >

Aprotinin/抑肽酶 生物活性

描述 Aprotinin is an inhibitor of serine protease which can inhibit trypsin and chymotrypsin with Ki values of 0.06 pM and 9 nM[3]. Aprotinin is also a competitive protein inhibitor of NOS activity. It inhibits NOS-I and NOS-II with Ki values of 50 μM and 78 μM, respectively[4]. Aprotinin significantly inhibits fibrinolysis with an IC50 of 0.16±0.05 μM[5]. In liver transplantation, the use of aprotinin is associated with a significant reduction in blood loss and transfusion requirements of around 30-40%[6]. Aprotinin significantly inhibited the growth of human breast cancer cell lines MDA-MB-231, SK-BR-3 and MCF-7, and normal fibroblast cell line HDF-1. Inhibition of local invasion by aprotinin was significant only in the case of MDA-MB-231[7]. Aprotinin can reduce degradation of fibrin sutures without significant effects on MSC (human mesenchymal stem cell) function[8].

Aprotinin/抑肽酶 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00372957 Diabetes Mellitus, Type 2 Phase 2 Completed - -
NCT03423069 Irritable Bowel Syndrome Not Applicable Recruiting December 31, 2020 Italy ... 展开 >> IRCCS Saverio de Bellis Recruiting Castellana Grotte, Bari, Italy, 70013 Contact: Giuseppe Riezzo    00390804994 ext 274    giuseppe.riezzo@irccsdebellis.it 收起 <<
NCT00372957 - Completed - -

Aprotinin/抑肽酶 参考文献

[1]Sperzel M, Huetter J. Evaluation of aprotinin and tranexamic acid in different in vitro and in vivo models of fibrinolysis, coagulation and thrombus formation. J Thromb Haemost. 2007 Oct;5(10):2113-8.

[2]Fritz H, Wunderer G. Biochemistry and applications of aprotinin, the kallikrein inhibitor from bovine organs. Arzneimittelforschung. 1983;33(4):479-94.

[3]Fritz H, Wunderer G. Biochemistry and applications of aprotinin, the kallikrein inhibitor from bovine organs. Arzneimittelforschung. 1983;33(4):479-94

[4]Venturini G, Colasanti M, Ascenzi P. Aprotinin, the first competitive protein inhibitor of NOS activity. Biochem Biophys Res Commun. 1998 Aug 10;249(1):263-5

[5]Davis R, Whittington R. Aprotinin. A review of its pharmacology and therapeutic efficacy in reducing blood loss associated with cardiac surgery. Drugs. 1995 Jun;49(6):954-83

[6]Pereboom IT, de Boer MT, Porte RJ, Molenaar IQ. Aprotinin and nafamostat mesilate in liver surgery: effect on blood loss. Dig Surg. 2007;24(4):282-7

[7]Soleyman-Jahi S, Sadeghi F, Afshari Z, Barati T, Ghasemi S, Muhammadnejad S, Amanpour S, Zendehdel K. Anti-neoplastic effects of aprotinin on human breast cancer cell lines: In vitro study. Adv Clin Exp Med. 2019 Feb;28(2):151-157

[8]Coffin ST, Gaudette GR. Aprotinin extends mechanical integrity time of cell-seeded fibrin sutures. J Biomed Mater Res A. 2016 Sep;104(9):2271-9

Aprotinin/抑肽酶 技术信息

CAS号9087-70-1
SMILES Code NONE
MDL No. MFCD00130541
别名 抑肽酶 ;Bovine Pancreatic Trypsin Inhibitor; BPTI; RP9921; HSDB7502
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月
溶解方案

DMSO: 65 mg/mL，配合低频超声，并调节pH至3，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL，配合低频超声助溶

配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一

Tags: Aprotinin | Bovine Pancreatic Trypsin Inhibitor;BPTI;RP9921;HSDB7502 | 抑肽酶 | Protease Inhibitor | Ser/Thr Protease | AmBeed-信号通路专用抑制剂 | Aprotinin/抑肽酶 纯度/质量文件 | Aprotinin/抑肽酶 生物活性 | Aprotinin/抑肽酶 临床数据 | Aprotinin/抑肽酶 参考文献 | Aprotinin/抑肽酶 技术信息

AmBeed 相关网站 AmBeed.cn AmBeed.com
AmBeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    AmBeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 AmBeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z