Ammonium glycyrrhizinate, a natural constituent of the licorice root that inhibits growth and cytopathology of several unrelated DNA and RNA viruses. A short-repeated treatment with ammonium glycyrrhizinate was able to attenuate neuropathic hyperalgesia in streptozotocin-induced diabetic mice. Ammonium glycyrrhizinate could ameliorate diabetic peripheral neuropathy, counteracting both in vitro and in vivo effects induced by high glucose, and might represent a complementary medicine for the clinical management of diabetic peripheral neuropathy[3]. Ammonium glycyrrhizinate (50, 100, 200 mg/kg, p.o.) is effective in controlling serum lipid profile and cardiac complications in experimentally induced cardiomyopathy in animals[4]. CAG (compound ammonium glycyrrhizin) as a potential therapeutic agent to counteract LPS/AC(lipopolysaccharide/amoxicillin clavulanate potassium)-induced liver injury[5]. LPS/ENR(Lipopolysaccharide/enrofloxacin)-treated hepatocytes were damaged via apoptotic signaling pathways and CAG prevented LPS/ENR-induced hepatocyte injury[6].
Ammonium glycyrrhizinate/甘草酸单铵 细胞实验
Cell Line
Concentration
Treated Time
Description
References
NCTC 2544 cells
0.03 mM
24 h
To evaluate the antioxidant activity of Ammonium glycyrrhizinate. The results showed that Ammonium glycyrrhizinate significantly reduced LDH release, indicating its antioxidant protective effect.
Pharmaceutics. 2021 Apr 14;13(4):548
goat cornea
50 μmol
120 min
Increasing the concentration of ammonium glycyrrhizinate to 50 μmol resulted in almost halved permeation of ascorbic acid, further confirming the role of Na+ transporters in ascorbic acid transport.
Saudi Pharm J. 2011 Jul;19(3):165-70
goat cornea
25 μmol
120 min
To evaluate the effect of ammonium glycyrrhizinate as a Na+K+-ATPase inhibitor on the permeation of ascorbic acid, showing significant reduction in permeation from 0.5% w/v ascorbic acid solution but no significant decrease from 1% w/v solution.
Single administration, effects observed 24-48 hours later
To evaluate the long-lasting anti-inflammatory and antinociceptive effects of AG 24-48 hours after a single administration. Results showed that AG exhibited significant anti-inflammatory effects in zymosan-induced paw edema and peritonitis models, and analgesic effects in various pain models.
Molecules. 2019 Jul 4;24(13):2453
CD-1 mice
Streptozotocin-induced diabetic mice model
Intraperitoneal injection
50 mg/kg
Administered on days 15, 17, and 19 after STZ injection, totaling 3 times
To evaluate the analgesic effects of ammonium glycyrrhizinate on diabetic neuropathy. Results showed that ammonium glycyrrhizinate significantly alleviated neuropathic pain in diabetic mice.
搜索
