Induction of squamous cell carcinoma, acceleration of diabetic symptoms
Cancer Sci. 2006 Oct;97(10):1023-30
Syrian hamsters
Pancreatic cancer model
Intravenous injection
60 mg/kg
Single dose, experiment lasted 46 weeks
To study the inhibitory effect of Alloxan on BOP-induced pancreatic cancer. Results showed that Alloxan administered 2 hours before BOP significantly inhibited pancreatic carcinogenesis (P<0.01).
Am J Pathol. 1983 Mar;110(3):310-4
C57BL/6J male mice
Diabetic model
Tail vein injection
65 mg/kg
Single injection, observed for 10 weeks
To induce diabetes and observe its effects on cardiac function, results showed increased LV tissue Hcy levels and impaired diastolic function in diabetic mice.
Int J Biol Sci. 2008 Aug 6;4(4):236-44
Swine
Alloxan-induced diabetes model
Intravenous injection
150 mg/kg
Single injection, observed for 0 to 90 days
To study the effect of Alloxan-induced diabetes on Müller cell contraction-promoting activity in swine vitreous, showing significant increases in activity in diabetic swine vitreous
Invest Ophthalmol Vis Sci. 2011 Sep 27;52(10):7485-91
New Zealand white rabbits
Alloxan-induced diabetic rabbit ear ulcer model
Ear vein injection
150 mg/kg
Single injection, observed until the end of the experiment
To induce a diabetic state and evaluate its effect on wound healing, results showed significantly delayed wound healing in diabetic rabbits.
Stem Cell Res Ther. 2013;4(6):158
Wistar rats
Alloxan-induced diabetic rat model
Intraperitoneal injection
50 mg/kg
Single injection
Induction of diabetes model, blood glucose levels significantly increased (21.83–27.01 mmol/L) after 72 hours.
To investigate the ameliorative effects of probiotic and vitamin C on hyperglycemia, oxidative stress, and dyslipidemia in alloxan-induced diabetic rats. Results showed that the combination of probiotic and vitamin C significantly reduced blood glucose levels, decreased malondialdehyde concentrations in serum, brain, and kidneys, and increased the activity of antioxidant enzymes.
Nutrients. 2016 May 5;8(5):151
Wistar rats
Diabetic model
Intraperitoneal injection
150 mg/kg
Single injection, duration four weeks
Induce diabetes and study the ameliorative effects of probiotic and vitamin C on hyperglycaemia, oxidative stress and dyslipidaemia
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