To investigate the effect of alliin on the expression of autophagy-related genes in cardiomyocytes under hypoxic conditions. Results showed that alliin significantly increased the expression levels of ATG4A, ATG4C, ATG4D, ATG9A, and ATG16L2.
PLoS One. 2016 Nov 28;11(11):e0165462
H9c2 cells
25, 100 and 200 µg/ml
4 hours
To evaluate the effect of alliin on apoptosis and necroptosis in H9c2 cells under hypoxic conditions. Results showed that alliin dose-dependently reduced apoptosis and necroptosis and inhibited the expression of RIP1, RIP3, and TRAF2.
PLoS One. 2016 Nov 28;11(11):e0165462
Primary cardiomyocytes
100 µg/ml
To investigate the effect of alliin on the expression of autophagy-related genes in cardiomyocytes under hypoxic conditions. Results showed that alliin significantly increased the expression levels of ATG4A, ATG4C, ATG4D, ATG9A, and ATG16L2.
Int J Mol Med. 2019 Nov;44(5):1943-1951
H9c2 cells
25, 100 and 200 µg/ml
4 hours
To evaluate the effect of alliin on apoptosis and necroptosis in H9c2 cells under hypoxic conditions. Results showed that alliin dose-dependently reduced apoptosis and necroptosis and inhibited the expression of RIP1, RIP3, and TRAF2.
Int J Mol Med. 2019 Nov;44(5):1943-1951
Alliin/蒜氨酸 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6 mice
Myocardial infarction model
Intraperitoneal injection
100 mg/kg
Administered daily starting 7 days before surgery and continued for 14 days after surgery
To evaluate the protective effect of alliin on cardiac function in mice with myocardial infarction. Results showed that alliin significantly reduced the infarct area, improved cardiac function, and decreased cardiomyocyte death and fibrosis.
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