Allantoin is the primary active compound in yams (Dioscorea spp.). Allantoin ameliorates the damage of β-cells induced by STZ (streptozotocin). The blockade by pharmacological inhibitors indicated that allantoin can activate the I3 (imidazoline 3) receptors through a PLC-related(phospholipase C) pathway to decrease this damage[3]. Allantoin has anti-inflammatory and wound healing properties. Allantoin had a considerable effect on gastritis treatment, which seems to result from the reinforcement of gastric mucosal barrier[4]. Allantoin decreased blood pressures in SHRs (spontaneous hypertensive rats) at 30 minutes, as the most effective time. Also, this antihypertensive action was shown in a dose-dependent manner from SHRs treated with allantoin. Moreover, in anesthetized rats, allantoin inhibited cardiac contractility and heart rate as showing in hemodynamic dP/dt max significantly. Also, the peripheral blood flow was markedly increased by allantoin[5]. The subchronic administration of allantoin (1, 3 or 10 mg/kg, for 7 days) significantly increased the latency time measured during the passive avoidance task in scopolamine-induced cholinergic blockade and normal naïve mice. In conclusion, allantoin has memory-enhancing effects, and these effects may be partly mediated by the PI3K-Akt-GSK-3β signal pathway[2].
United States, District of Col... 展开 >>umbia
The George Washington University Medical Faculty Associates
Washington, District of Columbia, United States, 20037 收起 <<
Prevention of Procedural Pain
... 展开 >>
Reduction of Procedural Pain
Biochemical Effects of Oral Sucrose 收起 <<
Not Applicable
Recruiting
August 2018
United States, California
... 展开 >>
Loma Linda University Children's Hospital
Recruiting
Loma Linda, California, United States, 92354
Contact: Danilyn M Angeles, PhD 909-558-7563 dangeles@llu.edu 收起 <<
Oxidative Stress
... 展开 >> Endothelial Function
Cardiovascular System
Hypertension 收起 <<
Not Applicable
Recruiting
December 31, 2020
Belgium
... 展开 >> Erasme Hospital
Recruiting
Brussels, Belgique, Belgium, 1070
Contact: Benjamin De Becker +32474328542 Benjamin.De.Becker@erasme.ulb.ac.be
Principal Investigator: Benjamin De Becker 收起 <<
United States, Pennsylvania
... 展开 >>
Altoona Center for Clincal Research
Duncansville, Pennsylvania, United States, 16635
United States, Texas
Metroplex Clinical Research Center
Dallas, Texas, United States, 75231 收起 <<
United States, California
... 展开 >>
Loma Linda Universtiy
Recruiting
Loma Linda, California, United States, 92350
Contact: Edward Bitok 909-558-4000 ext 47166 ebitok@llu.edu 收起 <<
Mexico
... 展开 >> Jefe del Departamento Dermatologia, Facultad de medicina y Hospital Universitario, Universidad Autonoma de Nuevo León
Monterrey Nuevo León, C.p., Mexico, 64460 收起 <<
United States, Arkansas
... 展开 >>
Baptist Health Center for Clinical Research
Little Rock, Arkansas, United States, 72205
United States, Florida
Miami Research Associates
Miami, Florida, United States, 33143
Orlando Clinical Research Center, Inc.
Orlando, Florida, United States, 32809
United States, Maryland
SNBL Clinical Pharmacology Center Inc.
Baltimore, Maryland, United States, 21201
United States, Minnesota
Davita Clinical Research
Minneapolis, Minnesota, United States, 55404
United States, Pennsylvania
Altoona Center for Clincal Research
Duncansville, Pennsylvania, United States, 16635 收起 <<
China, Shanghai
... 展开 >>
Center for Drug Clinical Research, Shanghai University of Chinese Medicine
Recruiting
Shanghai, Shanghai, China, 201203 收起 <<
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