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维生素D相关/核受体
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/ VD/VDR / Alfacalcidol/阿法骨化醇

Alfacalcidol/阿法骨化醇 {[allProObj[0].p_purity_real_show]}

货号：A462601 同义名： 1-hydroxycholecalciferol; 1.alpha.-Hydroxyvitamin D3

Alfacalcidol是一种维生素 D3 的衍生物，非选择性地激活维生素 D 受体 (VDR) ，用于骨质疏松相关的研究。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Alfacalcidol/阿法骨化醇 化学结构 CAS号：41294-56-8
Alfacalcidol/阿法骨化醇 化学结构
CAS号：41294-56-8
Alfacalcidol/阿法骨化醇 3D分子结构
CAS号：41294-56-8
Alfacalcidol/阿法骨化醇 化学结构 CAS号：41294-56-8
Alfacalcidol/阿法骨化醇 3D分子结构 CAS号：41294-56-8
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Alfacalcidol/阿法骨化醇 纯度/质量文件 产品仅供科研

货号：A462601 标准纯度： {[allProObj[0].p_purity_real_show]}
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Alfacalcidol/阿法骨化醇 生物活性

描述 Alfacalcidol is a non-selective VDR activator medication[3]. Alfacalcidol possesses immunoregulatory effects in vitro and in vivo by inhibiting the cytokines IL-1, IL-6, TNF-alpha and particularly IL-12. Therapy with alfacalcidol results in increased production of Th2 helper cells which produce bone protective cytokines like IL-4 and IL-10. Alfacalcidol retards corticosteroid-induced bone loss in contrast to plain vitamin D. Due to its immunomodulating properties, alfacalcidol is particularly suitable for RA(rheumatoid arthritis)-induced bone loss and for the prevention of transplantation osteoporosis, and an adjuvant contribution to the disease-modifying therapy of RA and to the immunosuppressive therapy after transplantation can not be excluded[4]. Alfacalcidol (0.025-0.1 mg/kg; p.o.; five times a week; for 3 months) exerts bone-protective effects independently of its Ca-related effects, and is in this respect superior to vitamin D(3), and that the skeletal actions of alfacalcidol take place, at least in part, independently of suppression of PTH(parathyroid hormone)[5].

Alfacalcidol/阿法骨化醇 细胞实验

Cell Line
Concentration Treated Time Description References
Huh7 cells 5.00 μM 6 days To evaluate the inhibitory effect of Alfacalcidol on SFTSV-induced cytopathic effect (CPE). The results showed that the EC50 value of Alfacalcidol was 1.59 ± 0.35 μM, indicating a dose-dependent protective effect against SFTSV infection. Virol Sin. 2024 Oct;39(5):802-811.
Huh7 cells 1.59 ± 0.35 μM(EC50) 6 days To evaluate the inhibitory effect of Alfacalcidol on SFTSV-induced cytopathic effect (CPE). The results showed that Alfacalcidol significantly inhibited SFTSV-induced CPE in a dose-dependent manner. Virol Sin. 2024 Oct;39(5):802-811.

Alfacalcidol/阿法骨化醇 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
ICR suckling mice Lethal SFTSV infection model Intraperitoneal injection 0.6 or 0.3 μg/kg Daily for 8 days To evaluate the therapeutic effect of Alfacalcidol on SFTSV-infected ICR suckling mice. The results showed that Alfacalcidol (0.6 μg/kg) provided 64% protection, significantly improving the survival rate of infected mice. Virol Sin. 2024 Oct;39(5):802-811.
ICR suckling mice SFTSV lethal infection model Intraperitoneal injection 0.6 or 0.3 μg/kg Once daily for 8 days To evaluate the therapeutic effect of Alfacalcidol on SFTSV-infected ICR suckling mice. The results showed that Alfacalcidol (0.6 μg/kg/d) provided 64% protection, significantly improving the survival rate of infected mice. Virol Sin. 2024 Oct;39(5):802-811.

Alfacalcidol/阿法骨化醇 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02069886 Thalassemia (Transfusion Delen... 展开 >>dent) 收起 << Phase 4 Withdrawn December 2018 -
NCT03483441 Basal Cell Nevus Syndrome ... 展开 >> Basal Cell Carcinoma 收起 << Phase 1 Recruiting May 1, 2023 United States, Arizona ... 展开 >> University of Arizona College of Medicine Not yet recruiting Phoenix, Arizona, United States, 85004 Contact: Nathalie Zeitouni, MD    602-406-8222    Nathalie.Zeitouni@dignityhealth.org    Sub-Investigator: Nathalie Zeitouni, MD          United States, Ohio Cleveland Clinic Recruiting Cleveland, Ohio, United States, 44195 Contact: Jeff Negrey, MA    216-636-5504    negreyj2@ccf.org    Principal Investigator: Edward Maytin, MD          Sub-Investigator: Christine Warren, MD 收起 <<
NCT02542865 Growth and Development Not Applicable Completed - India ... 展开 >> GSK Investigational Site Pune, India, 411001 收起 <<

Alfacalcidol/阿法骨化醇 参考文献

[1]Ivarsen P, Povlsen JV, et al. Effect of alfacalcidol on cardiac function in patients with chronic kidney disease stage 4 and secondary hyperparathyroidism: a pilot study. Scand J Urol Nephrol. 2012 Oct;46(5):381-8.

[2]Ringe JD, Schacht E. Prevention and therapy of osteoporosis: the roles of plain vitamin D and alfacalcidol. Rheumatol Int. 2004 Jul;24(4):189-97. Epub 2004 Jun 30.

[3]Pavlovic D, Katicic D, Gulin T, Josipovic J. Vitamin d in the patients with chronic kidney disease: when, to whom and in which form. Mater Sociomed. 2015 Apr;27(2):122-4

[4]Schacht E. Osteoporose bei rheumatoider Arthritis--Bedeutung von Alfacalcidol in Prävention und Therapie [Osteoporosis in rheumatoid arthritis--significance of alfacalcidol in prevention and therapy]. Z Rheumatol. 2000;59 Suppl 1:10-20. German

[5]Shiraishi A, Higashi S, Ohkawa H, Kubodera N, Hirasawa T, Ezawa I, Ikeda K, Ogata E. The advantage of alfacalcidol over vitamin D in the treatment of osteoporosis. Calcif Tissue Int. 1999 Oct;65(4):311-6

Alfacalcidol/阿法骨化醇 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.50mL

0.50mL

0.25mL

12.48mL

2.50mL

1.25mL

24.96mL

4.99mL

2.50mL

Alfacalcidol/阿法骨化醇 技术信息

CAS号41294-56-8
分子式C27H44O2
分子量 400.64
SMILES Code C=C1[C@H](C[C@@H](C/C1=C/C=C2[C@]3([C@@](C)([C@H](CC3)[C@@H](CCCC(C)C)C)CCC/2)[H])O)O
MDL No. MFCD00868328
别名 1-hydroxycholecalciferol; 1.alpha.-Hydroxyvitamin D3; EB 644; alpha-Calcidol; Alpha D 3; Alfarol; Tevabone; Oxydevit; Etalpha; Bondiol; 1-hydroxy Vitamin D3
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, store in freezer, under -20°C
溶解方案

DMSO: 50 mg/mL(124.8 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三

Tags: Alfacalcidol | 41294-56-8 | 1-hydroxycholecalciferol | 1.alpha.-Hydroxyvitamin D3 | VDR Activator | Vitamin D Related/Nuclear Receptor | VD/VDR | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Alfacalcidol/阿法骨化醇 纯度/质量文件 | Alfacalcidol/阿法骨化醇 生物活性 | Alfacalcidol/阿法骨化醇 临床数据 | Alfacalcidol/阿法骨化醇 参考文献 | Alfacalcidol/阿法骨化醇 实验方案 | Alfacalcidol/阿法骨化醇 技术信息

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