Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
药物研究 抗生素和抗病毒 囊泡
/
抗感染
小分子阳性药 功能 外泌体
/
单纯疱疹病毒
抗病毒
/ Acyclovir/阿昔洛韦

Acyclovir/阿昔洛韦 {[allProObj[0].p_purity_real_show]}

货号：A118981 同义名： 阿昔洛韦 / Aciclovir; Acycloguanosine

Acyclovir是一种高效的疱疹单纯病毒（HSV）1型和2型以及带状疱疹病毒的抑制剂，作为一种丙烯酸嘌呤核苷类似物。

Acyclovir/阿昔洛韦 化学结构 CAS号：59277-89-3
Acyclovir/阿昔洛韦 化学结构
CAS号：59277-89-3
Acyclovir/阿昔洛韦 3D分子结构
CAS号：59277-89-3
Acyclovir/阿昔洛韦 化学结构 CAS号：59277-89-3
Acyclovir/阿昔洛韦 3D分子结构 CAS号：59277-89-3
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price) ]} 		{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 1周 咨询 - +
购物车0 收藏 询单

Acyclovir/阿昔洛韦 纯度/质量文件 产品仅供科研

货号：A118981 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Nat. Electron., 2025, 8, 66-74. Ambeed. [ A100095 ]
• Adv. Mater., 2025, 2416621. Ambeed. [ A255324 , A420052 ]
• Adv. Mater., 2025, 2410493. Ambeed. [ A838608 ]
• Adv. Mater., 2025, 2420319. Ambeed. [ A106129 ]
更多 >

Acyclovir/阿昔洛韦 生物活性

描述 Acyclovir (aciclovir) is a nucleoside antiviral drug with antiviral activity in vitro against members of the herpes group of DNA viruses. As an established treatment of herpes simplex infection, intravenous, oral and to a lesser extent topical formulations of acyclovir provide significant therapeutic benefit in genital herpes simplex and recurrent orofacial herpes simplex. Ophthalmic application of 3% acyclovir ointment rapidly heals herpetic dendritic corneal ulcers and superficial herpetic keratitis[3]. Acyclovir is a selective antiherpes agent. Its selective activity is by exploitation of differences between the herpes-specific and host cell enzymes. In immunocompromised patients, acyclovir is effective for the prophylaxis and therapy of herpes simplex virus infections and for the treatment of herpes zoster and varicella. In nonimmunocompromised patients, acyclovir is beneficial in the therapy of herpes keratoconjunctivitis and in the therapy of genital herpes, with maximal benefit seen in those patients who have primary genital herpes[4]. Acyclovir (aciclovir) is a nucleoside analogue antiviral drug related to cytarabine, idoxuridine, trifluridine and vidarabine. Orally and intravenously administered acyclovir were beneficial in initial genital herpes infections, and oral therapy shortened the duration of recurrent infections by 1 to 2 days but did not ameliorate pain[5].

Acyclovir/阿昔洛韦 细胞研究

细胞系 浓度 检测类型 检测时间 活性说明 数据源
African green monkey Vero 76 cells Cytotoxicity assay 48-96 h Cytotoxicity against African green monkey Vero 76 cells assessed as cell viability after 48 to 96 hrs by crystal violet staining, CC50=13 μM 26119992
african green monkey Vero cells Function assay 48 h Antiviral activity against HSV2 strain 333 infected in african green monkey Vero cells assessed as inhibition of cytopathic effect after 48 hrs by plaque reduction assay, EC50=1.87 μM 22704890
BSC-1 cells Function assay Antiviral activity of the compound was evaluated against the Herpes simplex virus type-1 in BSC-1 cells, IC50=2.6 μM 2913300
BSC-1 cells Function assay Effective concentration required to inhibit herpes simplex virus 1 in BSC-1 cells in ELISA, EC50=1.5 μM 15634003

Acyclovir/阿昔洛韦 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03443869 CMV Disease Phase 3 Recruiting September 19, 2021 -
NCT02157090 Herpes Simplex Labialis Not Applicable Completed - Germany ... 展开 >> University Hospital Carl Gustav Carus at the Technische Universität Dresden Dresden, Saxony, Germany, 01307 收起 <<
NCT00343278 Virus Diseases Phase 4 Completed - -

Acyclovir/阿昔洛韦 参考文献

[1]Tang IY, Maddux MS, et al. Low-dose oral acyclovir for prevention of herpes simplex virus infection during OKT3 therapy. Transplant Proc. 1989 Feb;21(1 Pt 2):1758-60.

[2]Meyrick Thomas RH, et al. Oral acyclovir in the suppression of recurrent non-genital herpes simplex virus infection. Br J Dermatol. 1985 Dec;113(6):731-5.

[3]O'Brien JJ, Campoli-Richards DM. Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy. Drugs. 1989 Mar;37(3):233-309

[4]Laskin OL. Acyclovir. Pharmacology and clinical experience. Arch Intern Med. 1984 Jun;144(6):1241-6

[5]Richards DM, Carmine AA, Brogden RN, Heel RC, Speight TM, Avery GS. Acyclovir. A review of its pharmacodynamic properties and therapeutic efficacy. Drugs. 1983 Nov;26(5):378-438

Acyclovir/阿昔洛韦 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.44mL

0.89mL

0.44mL

22.20mL

4.44mL

2.22mL

44.40mL

8.88mL

4.44mL

Acyclovir/阿昔洛韦 技术信息

CAS号59277-89-3
分子式C8H11N5O3
分子量 225.2
SMILES Code C1=NC2=C([N]1COCCO)NC(=NC2=O)N
MDL No. MFCD00057880
别名 阿昔洛韦 ;Aciclovir; Acycloguanosine; NSC 645011; ACV; BW 248U
运输蓝冰
InChI Key MKUXAQIIEYXACX-UHFFFAOYSA-N
Pubchem ID 135398513
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, 2-8°C
溶解方案

DMSO: 50 mg/mL(222.02 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

Tags: Acyclovir | Aciclovir;Acycloguanosine;NSC 645011;ACV;BW 248U | 阿昔洛韦 | Antivirus | HSV | AmBeed-信号通路专用抑制剂 | Acyclovir/阿昔洛韦 纯度/质量文件 | Acyclovir/阿昔洛韦 生物活性 | Acyclovir/阿昔洛韦 细胞研究 | Acyclovir/阿昔洛韦 临床数据 | Acyclovir/阿昔洛韦 参考文献 | Acyclovir/阿昔洛韦 实验方案 | Acyclovir/阿昔洛韦 技术信息

Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 Ambeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z