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ATP/三磷酸腺苷 {[allProObj[0].p_purity_real_show]}

货号：A160197 同义名： 腺苷三磷酸 / Adenosine triphosphate; Adenosine 5'-triphosphate

ATP is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells.

ATP/三磷酸腺苷 化学结构 CAS号：56-65-5
ATP/三磷酸腺苷 化学结构
CAS号：56-65-5
ATP/三磷酸腺苷 3D分子结构
CAS号：56-65-5
ATP/三磷酸腺苷 化学结构 CAS号：56-65-5
ATP/三磷酸腺苷 3D分子结构 CAS号：56-65-5
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ATP/三磷酸腺苷 纯度/质量文件 产品仅供科研

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ATP/三磷酸腺苷 生物活性

描述 Adenosine 5'-triphosphate (ATP) is a crucial component of energy storage and metabolism within the body. It not only provides the metabolic energy required for operating metabolic pumps but also acts as a coenzyme in various cellular processes. Additionally, ATP plays a significant role as an endogenous signaling molecule in immune responses and inflammation[1].[2].
体内研究

Furthermore, ATP induces the secretion of inflammatory cytokines and recruits neutrophils in vivo, enhancing immune responses[4].
体外研究

When combined with LPS (1 μg/mL) at a concentration of 5 mM for one hour, ATP exhibits a synergistic effect on the activation of the NLRP3 inflammasome in human gingival fibroblasts (HGFs)[3].

At a concentration of 2 mM, ranging from 0.5 to 24 hours, ATP triggers the secretion of IL-1β, KC, and MIP-2 from bone marrow-derived macrophages (BMDMs) in a manner dependent on caspase-1 activation[4].

ATP also facilitates neutrophil chemotaxis in vitro and protects mice against bacterial infections when administered intraperitoneally at a dose of 50 mg/kg[4].

ATP/三磷酸腺苷 参考文献

[1]Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8.

[2]M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404.

[3]Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514.

[4]Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759.

ATP/三磷酸腺苷 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.97mL

0.39mL

0.20mL

9.86mL

1.97mL

0.99mL

19.72mL

3.94mL

1.97mL

ATP/三磷酸腺苷 技术信息

CAS号56-65-5
分子式C10H16N5O13P3
分子量 507.18
SMILES Code O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3COP(O)(OP(O)(OP(O)(O)=O)=O)=O
MDL No. MFCD00065467
别名 腺苷三磷酸 ;Adenosine triphosphate; Adenosine 5'-triphosphate; Triphosphoric acid adenosine ester; Triphosphaden; Atipi; Ara-ATP
运输蓝冰
InChI Key ZKHQWZAMYRWXGA-KQYNXXCUSA-N
Pubchem ID 5957
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C
溶解方案

H2O: 100 mg/mL(197.17 mM)

配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案一

Tags: ATP | Adenosine triphosphate;Adenosine 5'-triphosphate;Triphosphoric acid adenosine ester;Triphosphaden;Atipi;Ara-ATP | 腺苷三磷酸 | AmBeed-信号通路专用抑制剂 | ATP/三磷酸腺苷 纯度/质量文件 | ATP/三磷酸腺苷 生物活性 | ATP/三磷酸腺苷 参考文献 | ATP/三磷酸腺苷 实验方案 | ATP/三磷酸腺苷 技术信息

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