There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
To investigate the effect of 680C91 on mRNA expression in fibroid explants, results showed that 680C91 blocked tryptophan-induced expression of CYP1B1, TGF-β3, FN1, CDK2, E2F1, IL8, and SPARC mRNA.
Fertil Steril. 2024 Apr;121(4):669-678.
HCT15 colon cancer cells
25 µM
3 days
Reduction in cell number was caused by cell death or cell cycle arrest
Genes Dev. 2019 Sep 1;33(17-18):1236-1251.
DLD1 colon cancer cells
25 µM
3 days
Reduction in cell number was caused by cell death or cell cycle arrest
Genes Dev. 2019 Sep 1;33(17-18):1236-1251.
SK-Mel-28 melanoma cells
40 μM
24 hours
680C91 significantly inhibited dexamethasone-induced migration and MMP2 activity in SK-Mel-28 cells.
Pharmaceuticals (Basel). 2021 Mar 4;14(3):211.
SK-Mel-28 melanoma cells
40 μM
3 hours
680C91 partially but significantly inhibited dexamethasone-induced Akt phosphorylation.
Pharmaceuticals (Basel). 2021 Mar 4;14(3):211.
SK-Mel-28 melanoma cells
40 μM
48 hours
680C91 significantly inhibited dexamethasone-induced proliferation of SK-Mel-28 cells by 41.2 ±7.1%, without affecting cell viability or FGF2-induced cell proliferation.
Pharmaceuticals (Basel). 2021 Mar 4;14(3):211.
A172 cells
10 μM
24 hours
680C91 treatment resulted in decreased hpol κ expression.
Chem Res Toxicol. 2016 Jan 19;29(1):101-8.
U-87-MG cells
10 μM
24 hours
680C91 treatment resulted in decreased hpol κ expression.
Chem Res Toxicol. 2016 Jan 19;29(1):101-8.
T98G cells
10 μM or 100 μM
24 hours
Inhibition of TDO activity led to reduced Kyn production and decreased hpol κ expression levels.
680C91 significantly inhibited HUVEC proliferation, with maximal effect at 40 µM inhibiting cell growth by 79.3 ± 28%
Pharmaceuticals (Basel). 2024 Apr 27;17(5):558.
A375 cells
40 µM
24 hours
680C91 significantly abolished the dex-induced upregulation of stem cell markers
Front Pharmacol. 2022 Jun 30;13:911019.
SK-Mel-28 cells
40 µM
24 hours
680C91 significantly abolished the dex-induced upregulation of stem cell markers
Front Pharmacol. 2022 Jun 30;13:911019.
HepG2 cells
10, 20, 40, 80 µmol/L
72 hours
To investigate the effect of 680C91 on TDO-mediated tryptophan degradation, results showed that 680C91 significantly inhibited tryptophan degradation and kynurenine accumulation
J Clin Med. 2022 Aug 16;11(16):4794.
680C91 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
SCID/Beige mice
Human fibroid xenograft model
Intraperitoneal injection
10 mg/kg
Daily for two months
To evaluate the therapeutic effects of 680C91 on fibroid xenografts, results showed a 30% reduction in fibroid weight after two months of treatment with 680C91, along with decreased levels of kynurenine and reduced mRNA and protein expression of multiple genes (CYP1B1, TGF-β3, FN1, CDK2, E2F1, IL-8, and SPARC) in the xenografts.
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