There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
DOK cells were transformed by 4-NQO to generate DOK-4-NQO cell line for in vitro and in vivo tumorigenicity studies.
Redox Biol. 2024 Oct;76:103335
4-Nitroquinoline N-oxide/4-硝基氮氧化喹啉 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
4-NQO-induced ESCC mouse model
Drinking water
100 mg/L
16 weeks
To study the effect of SENP3 deletion on ESCC progression, results showed increased tumor numbers in Senp3 cKO mice.
Cell Commun Signal. 2024 Aug 9;22(1):395
Mice
4-NQO-induced oral carcinogenesis model
Drinking water
100 μg/mL
Weekly for 16 weeks
Assessed the effect of 4-NQO on oral carcinogenesis, showing that 4-NQO treatment significantly promotes the occurrence and development of oral cancer.
Redox Biol. 2024 Oct;76:103335
Mice
IP6K2 knockout mice
Drinking water
100 μg/ml
Continuous for 23 weeks
To evaluate the carcinogenic effect of 4-NQO on IP6K2 knockout mice, results showed a fourfold increased incidence of invasive squamous cell carcinoma in the oral cavity and esophagus of KO mice compared to wild-type littermates
Oncogene. 2009 Jun 25;28(25):2383-92
Mice
CD24-deficient and CD24-heterozygous mice
Drinking water
50 µg/mL
16 weeks
To investigate the role of CD24 in oral cancer development. Results showed that CD24-deficient mice were more susceptible to 4-NQO-induced oral carcinogenesis with significantly increased tumor burden.
Oncoimmunology. 2016 Sep 26;5(10):e1226719
Mice
Grhl2 conditional knockout mouse model
Drinking water
30 μg/ml
16 weeks of 4-NQO exposure followed by 6 weeks of drug-free drinking water
To investigate the role of GRHL2 in oral carcinogenesis, results showed that Grhl2 KO mice completely abolished 4-NQO-induced tongue tumor formation.
Oncogenesis. 2018 May 8;7(5):38
BALB/C nude mice
4-NQO-induced HNSCC model
Drinking water
50 μg/mL
16 weeks
Establish an HNSCC tumorigenesis model, results showed that the protein expression of PSMD14 was significantly higher in low-grade dysplasia (Week 24) and high-grade dysplasia/carcinoma (Week 28) than in normal tissue (Week 16).
Theranostics. 2021 Jan 1;11(6):2655-2669
BALB/c nude mice
4-NQO-induced ESCC model
Oral administration via drinking water
50 μg/mL
16 weeks of exposure followed by 12 weeks of normal drinking water
To induce a murine ESCC model and investigate the expression of PSMD14 in esophageal tumorigenesis
Theranostics. 2021 Apr 3;11(12):5847-5862
C57BL/6J mice
Oral squamous cell carcinoma model
Drinking water
0.1 mg/mL
Once a week for 16 weeks
To induce the development and progression of oral squamous cell carcinoma for evaluating the therapeutic effects of TGF-β inhibitors and anti-PD-L1 antibodies.
Mol Cancer Ther. 2021 Jun;20(6):1102-1111
C57BL/6J mice
4-NQO-induced spontaneous ESCC mouse model
Drinking water
100 μg/mL
16 weeks
To induce spontaneous esophageal squamous cell carcinoma and verify the antitumor activity of the CCL18-blocking peptide Pep3.
J Exp Clin Cancer Res. 2023 Feb 27;42(1):51
4-Nitroquinoline N-oxide/4-硝基氮氧化喹啉 动物研究
Animal study
食管肿瘤模型
动物：CD276wKO+CD276cKO小鼠，雄性，6周龄。
给药：50 μg/ mL ，食用水饮用，连续16周。
4-Nitroquinoline N-oxide/4-硝基氮氧化喹啉 实验方案
计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
5.26mL
1.05mL
0.53mL
26.30mL
5.26mL
2.63mL
52.59mL
10.52mL
5.26mL
4-Nitroquinoline N-oxide/4-硝基氮氧化喹啉 技术信息
CAS号
56-57-5
分子式
C9H6N2O3
分子量
190.15
SMILES Code
O=[N+](C1=C2C=CC=CC2=[N+]([O-])C=C1)[O-]
MDL No.
MFCD00006738
别名
4-硝基喹啉-N-氧化物
;4-NQO; Nitrochin
运输
蓝冰
InChI Key
YHQDZJICGQWFHK-UHFFFAOYSA-N
Pubchem ID
5955
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formInert atmosphere, store in freezer, under -20°C
搜索
HazMat Fee +
