3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 µM; has anti-inflammatory, anti-proliferative and anti-HIV activity.
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3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 µM; has anti-inflammatory, anti-proliferative and anti-HIV activity.
3-Deazaadenosine/3-脱氮腺苷 细胞实验
Cell Line
Concentration
Treated Time
Description
References
HepG2 cells
40 µM
2 hours
To investigate the dose-dependent effect of DZA on TNF-induced cytotoxicity, results showed that DZA pretreatment increased TNF-induced cell death in a dose-dependent manner.
Biochem Pharmacol. 2007 Aug 1;74(3):521-31.
3T3-L1 adipocytes
50 µM and 100 µM
48 hours
To investigate the effect of DZA on adipocyte lipolysis. Results showed that DZA treatment increased the release of glycerol and free fatty acids, decreased intracellular triglyceride content, activated ATGL and HSL, reduced adipocyte differentiation factors, impaired adiponectin and leptin secretion, but increased the release of pro-inflammatory cytokines IL-6, TNF, and MCP-1.
Sci Rep. 2021 Jul 19;11(1):14693.
Primary adipocytes
100 μM
6 h
To investigate the effect of betaine on methylation status in adipocytes, results showed DZA reduced intracellular SAM:SAH ratio.
Br J Pharmacol. 2014 Sep;171(17):4073-86
3T3-L1 adipocytes
100 μM
24 h
To investigate the effect of betaine on lipolytic response in adipocytes, results showed DZA treatment increased glycerol release.
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