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/ 3,3',5-Triiodo-L-thyronine/甲碘安

3,3',5-Triiodo-L-thyronine/甲碘安 {[allProObj[0].p_purity_real_show]}

货号：A267480 同义名： 三碘甲状腺原氨酸 / Triiodothyronine; T3

3,3',5-Triiodo-L-thyronine是一种甲状腺激素激动剂，具有较强的 TRα 和 TRβ 激动作用，Ki 值分别为 2.33 和 2.29 nM，适用于影响代谢等生理过程的研究。

3,3',5-Triiodo-L-thyronine/甲碘安 化学结构 CAS号：6893-02-3
3,3',5-Triiodo-L-thyronine/甲碘安 化学结构
CAS号：6893-02-3
3,3',5-Triiodo-L-thyronine/甲碘安 3D分子结构
CAS号：6893-02-3
3,3',5-Triiodo-L-thyronine/甲碘安 化学结构 CAS号：6893-02-3
3,3',5-Triiodo-L-thyronine/甲碘安 3D分子结构 CAS号：6893-02-3
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3,3',5-Triiodo-L-thyronine/甲碘安 纯度/质量文件 产品仅供科研

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全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
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• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
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3,3',5-Triiodo-L-thyronine/甲碘安 生物活性

靶点

  • JNK1

    JNK1, Kd:240 nM

  • JNK2

    JNK2, Kd:290 nM

  • JNK3

    JNK3, Kd:66 nM
描述 Liothyronine represents an active thyroid hormone variant. It acts as a powerful agonist for the thyroid hormone receptors TRα and TRβ, exhibiting Ki values of 2.33 nM for both hTRα and hTRβ, respectively[1].[2].[3]. Produced in accordance with GMP guidelines, Liothyronine (Triiodothyronine) (GMP), also known as Liothyronine, functions effectively as a supportive reagent in cell therapy production. It serves as a strong agonist for the thyroid hormone receptors TRα and TRβ with Ki values of 2.33 nM for each, hTRα and hTRβ, respectively[1].
体外研究

In cases where TRβ1 is upregulated, liothyronine (100 nM) enhances the growth of hepatocarcinoma cells[1].

The binding of liothyronine to the human β1 thyroid hormone receptor (hTRβ1) alters its structure, thereby fostering cellular growth, promoting differentiation, and regulating metabolic processes[2].

Liothyronine (GMP) is utilized in the culture mediums essential for generating induced pluripotent stem cells from human keratinocytes[1].

Additionally, it is crucial for the proliferation and self-renewal of limbal stem cells (LSCs)[2].

At a concentration of 4 nM, Liothyronine (GMP) encourages the cardiac differentiation and maturation of embryonic stem cells[3].

Furthermore, Liothyronine (GMP) at 100 Nm over 14 days, enhances the electrophysiological maturation of cardiomyocytes derived from human-induced pluripotent stem cells (hiPSC)[4].

3,3',5-Triiodo-L-thyronine/甲碘安 细胞实验

Cell Line
Concentration Treated Time Description References
HepG2 cells 0.1 µM 16 hours To evaluate the effect of thyroid hormone on ACBP/DBI expression, results showed that T3 reduced ACBP/DBI expression Nat Metab. 2024 Dec;6(12):2281-2299.
H4 human neuroglioma cells 0.1 µM 16 hours To evaluate the effect of thyroid hormone on ACBP/DBI expression, results showed that T3 reduced ACBP/DBI expression Nat Metab. 2024 Dec;6(12):2281-2299.
Brown adipocyte precursor cell line (BAC) 100 nM 24 hours To investigate the effect of T3 on Myc promoter activity, results showed that T3 directly regulates Myc transcription via TRα. Nat Commun. 2022 Jun 13;13(1):3394.
White adipocytes 100 nM 24 hours To evaluate the effects of different T3 delivery forms on browning of white adipocytes, results showed that 5%PLT3 significantly induced the expression of Ucp1 and Pgc1α Nat Commun. 2022 Dec 20;13(1):7838.
Mouse BAT stromal vascular fractions (SVFs) 15 nM or 50 nM 25 days To assess the effect of Dio3os knockdown on brown adipocyte differentiation. Dio3os knockdown reduced lipid droplet formation and expression of mitochondrial biogenesis-related genes. T3 supplementation dose-dependently rescued brown adipocyte differentiation. Nat Commun. 2021 Nov 25;12(1):6845.
Mouse embryonic fibroblasts (MEFs) 50 nM 6 days To assess the effect of Dio3os knockdown on brown adipocyte differentiation. Dio3os knockdown activated Dio3 expression, reduced intracellular T3 levels, and inhibited brown adipocyte differentiation. T3 supplementation reversed these effects. Nat Commun. 2021 Nov 25;12(1):6845.
White pre-adipocytes 100 nM 48 hours To investigate the effect of T3 on UCP1 expression in Mkk6−/− white pre-adipocytes, results showed Mkk6−/− cells were more sensitive to T3 stimulation, with higher UCP1 expression. Nat Commun. 2017 Oct 11;8(1):856.
Primary brown adipocytes 1 nM 4 days Promote differentiation and function of brown adipocytes Nat Commun. 2017 Jan 27;8:14147.
Mouse lung epithelial cells (MLE12) 15 ng/ml 8 hours To evaluate the effect of T3 on bleomycin-induced mitochondrial dysfunction, results showed T3 significantly increased mitochondrial membrane potential and oxygen consumption rate. Nat Med. 2018 Jan;24(1):39-49.
Primary mouse AECIIs 15 ng/ml 8 hours To evaluate the effect of T3 on bleomycin-induced mitochondrial dysfunction, results showed T3 significantly increased mitochondrial membrane potential and oxygen consumption rate. Nat Med. 2018 Jan;24(1):39-49.
Human small airway epithelial cells (SAECs) 15 ng/ml 8 hours To evaluate the effect of T3 on bleomycin-induced mitochondrial dysfunction, results showed T3 significantly increased mitochondrial membrane potential and oxygen consumption rate. Nat Med. 2018 Jan;24(1):39-49.
MRC5 (human fetal lung fibroblasts) 10 nM 24 hours To evaluate the effects of TRα and TRβ activation on cell proliferation, TRα activation significantly promoted cell proliferation, while TRβ activation had minimal effect Nat Commun. 2024 Oct 7;15(1):8672.
Mouse primary lung macrophages 10 nM T3 24 h upregulate Trem2 expression and downregulate Il6 and Il1b expression Cell Chem Biol. 2022 Feb 17;29(2):239-248.e4.
Mouse macrophage cell line RAW 264.7 10 nM T3 24 h upregulate Trem2 in mouse macrophage cell line RAW 264.7 Cell Chem Biol. 2022 Feb 17;29(2):239-248.e4.

3,3',5-Triiodo-L-thyronine/甲碘安 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Male C57BL/6 mice Hypothyroid mouse model Intraperitoneal injection 0.25 μg/g body weight (standard dose) Once daily for 5 days To investigate the effect of T3 on hyperplasia and thermogenic capacity of interscapular BAT (iBAT), results showed that long-term T3 treatment increases iBAT hyperplasia and thermogenic capacity by promoting adipocyte progenitor cell (APCs) proliferation. Nat Commun. 2022 Jun 13;13(1):3394.
Mice Pregnant dams Drinking water 0.5 mg/L From conception to gestational day (GD) 17 Maternal T3 treatment leads to improved glucose tolerance in the adult male offspring and hyperactivity of brown adipose tissue (BAT) thermogenesis in both sexes starting early after birth. Nat Commun. 2023 Oct 24;14(1):6742
C57BL/6N mice High-fat diet-induced obese mouse model Intraperitoneal injection 50 μg/kg body weight Every two days for 32 days To evaluate the therapeutic effects of PLT3 on obesity and related metabolic complications, results showed that PLT3 significantly alleviated obesity, improved glucose intolerance and insulin resistance with negligible side effects Nat Commun. 2022 Dec 20;13(1):7838.
Mice Mkk6−/− mice Intraperitoneal injection 3 μg/100 g Daily for 8 weeks To investigate the effect of T3 on WAT browning in Mkk6?/? mice, results showed Mkk6?/? mice were more sensitive to T3, with increased UCP1 expression, higher energy expenditure, and resistance to HFD-induced obesity. Nat Commun. 2017 Oct 11;8(1):856.
Mice A-FABP knockout mice Subcutaneous injection 500 μg/kg 1 day Investigate the effect of T3 on energy expenditure in A-FABP knockout mice Nat Commun. 2017 Jan 27;8:14147.

3,3',5-Triiodo-L-thyronine/甲碘安 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02133040 - Active, not recruiting May 10, 2020 Denmark ... 展开 >> Aarhus University Hospital Aarhus, Region Midtjylland, Denmark, 8000 收起 <<
NCT02398344 Stroke Phase 1 Phase 2 Completed - Brazil ... 展开 >> University of Nove de Julho São Paulo, Brazil 收起 <<
NCT02733497 Hyperhidrosis Not Applicable Completed - -

3,3',5-Triiodo-L-thyronine/甲碘安 参考文献

[1]Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94.

[2]Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92.

[3]CY, et al. Triiodothyronine promotes cardiac differentiation and maturation of embryonic stem cells via the classical genomic pathway. Mol Endocrinol. 2010 Sep;24(9):1728-36.

[4]Wang L, et al. Triiodothyronine and dexamethasone alter potassium channel expression and promote electrophysiological maturation of human-induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2021 Dec;161:130-138.

3,3',5-Triiodo-L-thyronine/甲碘安 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.54mL

0.31mL

0.15mL

7.68mL

1.54mL

0.77mL

15.36mL

3.07mL

1.54mL

3,3',5-Triiodo-L-thyronine/甲碘安 技术信息

CAS号6893-02-3
分子式C15H12I3NO4
分子量 650.97
SMILES Code O=C(O)[C@@H](N)CC1=CC(I)=C(OC2=CC=C(O)C(I)=C2)C(I)=C1
MDL No. MFCD00002593
别名 三碘甲状腺原氨酸 ;Triiodothyronine; T3; NSC 80203; L-3,3’,5-Triiodothyronine; 3,3’,5-Triiodo-L-thyronine; Liothyronine
运输蓝冰
InChI Key AUYYCJSJGJYCDS-LBPRGKRZSA-N
Pubchem ID 5920
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place,Sealed in dry,2-8°C
溶解方案

DMSO: 50 mg/mL(76.81 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

1M NaOH: 50 mg/mL(76.81 mM)，配合低频超声助溶

Tags: Liothyronine (GMP) | 6893-02-3 | Triiodothyronine (GMP) | 3,3',5-Triiodo-L-thyronine (GMP) | T3 (GMP) | TRα/TRβ Agonist (GMP) | Vitamin D Related/Nuclear Receptor | Thyroid Hormone Receptor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | 3,3',5-Triiodo-L-thyronine/甲碘安 纯度/质量文件 | 3,3',5-Triiodo-L-thyronine/甲碘安 生物活性 | 3,3',5-Triiodo-L-thyronine/甲碘安 临床数据 | 3,3',5-Triiodo-L-thyronine/甲碘安 参考文献 | 3,3',5-Triiodo-L-thyronine/甲碘安 实验方案 | 3,3',5-Triiodo-L-thyronine/甲碘安 技术信息

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