/β-Glycerophosphate disodium salt pentahydrate/二钠五水合物
β-Glycerophosphate disodium salt pentahydrate/二钠五水合物
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货号：A130983同义名：
五水β-甘油磷酸钠(二钠五水合物);五水β-甘油磷酸钠
/ β-Glycerophosphate (sodium salt hydrate); β-Glycerophosphate sodium salt hydrate
β-Glycerophosphate disodium salt pentahydrate是一种内源性代谢物，常用作有机磷酸供体和丝氨酸/苏氨酸磷酸酶的抑制剂。在细胞生物学研究中，β-GP通过提供磷酸基团，促进基质矿化，常用于成骨细胞分化实验。此外，β-GP可加速血管平滑肌细胞的钙化，并在组织工程中作为水凝胶或支架的组分。
β-Glycerophosphate disodium salt pentahydrate/二钠五水合物 化学结构 CAS号：13408-09-8
β-Glycerophosphate disodium salt pentahydrate/二钠五水合物 3D分子结构 CAS号：13408-09-8
β-Glycerophosphate disodium salt pentahydrate/二钠五水合物 质控信息
β-Glycerophosphate disodium salt pentahydrate/二钠五水合物 生物活性
描述
β-Glycerophosphate disodium salt pentahydrate functions as an inhibitor of phosphatases[1].
β-Glycerophosphate disodium salt pentahydrate/二钠五水合物 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Mesenchymal stem cells
0.6 M and 1.0 M
21 days
To test the effect of different concentrations of β-GPS on MSC differentiation, results showed 0.6 M β-GPS promoted neural cell differentiation, while 1.0 M β-GPS promoted adipocyte differentiation
Bioact Mater. 2020 Jun 22;5(4):808-818.
Fibroblasts
1.0 M
14 days
To test the effect of β-GPS on fibroblast proliferation and adhesion, results showed higher expression of proliferation and adhesion markers at 14 days compared to 7 days
Bioact Mater. 2020 Jun 22;5(4):808-818.
C2C12 cells
10 mM
7 days
To evaluate the effect of high phosphate concentration on the myogenic differentiation of C2C12 cells. Results showed that cells treated with BGP exhibited significantly lower expression of troponin T and maintained higher levels of Pax-7, indicating that BGP inhibited myogenic differentiation.
To investigate the effect of β-GP on BK channel function in MOVAS cells. Results showed that β-GP-treated MOVAS cells were less sensitive to outward currents, indicating impaired BK channel function.
Acta Pharmacol Sin. 2022 Mar;43(3):624-633.
Rat vascular smooth muscle cells
10 mM
7 days
To investigate the effect of β-GP-induced calcification on the expression of BK channels in rat vascular smooth muscle cells. Results showed that β-GP-induced calcification decreased the expression of BK channels and α-SMA, while increasing the expression of Runx2.
Acta Pharmacol Sin. 2022 Mar;43(3):624-633.
Mouse vascular smooth muscle cells (VSMC)
10 mM
7 days
Induced VSMC calcification and observed increased pyroptosis and calcium deposition. Results showed that β-GP treatment significantly increased calcium deposition and the expression of pyroptosis-related proteins in VSMCs.
Cell Death Dis. 2022 Mar 30;13(3):283.
Human Gingival Mesenchymal Stem Cells (HGMSCs)
10 mM
21 days
Promote osteogenic differentiation of HGMSCs and increase the expression of autophagy markers
Cell Commun Signal. 2019 Aug 19;17(1):98.
human aortic smooth muscle cells (HAoSMCs)
10 mM
12 days
To investigate the effect of β-Glycerophosphate on osteogenic differentiation of HAoSMCs, results showed that OMD mRNA levels were significantly upregulated in osteogenic medium.
Clin Transl Med. 2022 Feb;12(2):e682.
human mesenchymal stromal cell (hMSC)-derived chondrogenic pellets
10 mM
2 weeks
Induction of in vitro cartilage mineralisation, resulting in loss of glycosaminoglycans, reduced expression of collagen II and X, and decreased VEGFA production.
Cells. 2023 Apr 20;12(8):1202.
MDA-MB-231 human breast cancer cells
10 mM
14 days
To investigate the effect of β-glycerophosphate on the mineralization of breast cancer cells, results showed that β-glycerophosphate-induced mineralization process was slower, beginning at day 11.
Lab Invest. 2021 Sep;101(9):1267-1280.
MC3T3-E1 pre-osteoblasts
10 mM
28 days
Induced osteogenic differentiation of MC3T3-E1 pre-osteoblasts, promoting the mineralization process.
Cells. 2022 Aug 30;11(17):2702.
β-Glycerophosphate disodium salt pentahydrate/二钠五水合物 参考文献
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