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/ 黑素皮质素受体 / α-MSH

α-MSH {[allProObj[0].p_purity_real_show]}

货号：A680820 同义名： α-Melanocyte-Stimulating Hormone

α-MSH是一种从植物提取的天然产物，具有抗过敏和抗血管生成作用，可通过调节 IL-4 和 IFN-γ 表达发挥作用，适用于骨质疏松和炎症性疾病的研究。

α-MSH 化学结构 CAS号：581-05-5
α-MSH 化学结构
CAS号：581-05-5
α-MSH 3D分子结构
CAS号：581-05-5
α-MSH 化学结构 CAS号：581-05-5
α-MSH 3D分子结构 CAS号：581-05-5
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α-MSH 纯度/质量文件 产品仅供科研

货号：A680820 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
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α-MSH 细胞实验

Cell Line
Concentration Treated Time Description References
H9c2 cells 0.1 nM 30 minutes Α-MSH significantly reduced JNK phosphorylation levels. EMBO Rep. 2024 Apr;25(4):1987-2014
H9c2 cells 0.1 nM 1, 3, 6, or 24 hours Α-MSH downregulated the expression of hypertrophy-related gene Nppb and fibrosis-related genes including Acta2, Tgfb1, Col3a1, and Fn1. EMBO Rep. 2024 Apr;25(4):1987-2014
B16F10 cells 10–30 µM 24 hours To evaluate the effect of Pt on melanogenesis-related protein expression in α-MSH-stimulated B16F10 cells. Results showed that Pt significantly downregulated the expression of MC1R, MITF, tyrosinase, TRP-1/-2, and melanin production. Redox Biol. 2021 Aug;44:102007.
HaCaT cells 2.5–5 µM 24 hours To evaluate the effect of Pt on UVA-induced ROS production and POMC/α-MSH pathway downregulation in HaCaT cells. Results showed that Pt significantly inhibited UVA-induced ROS production and α-MSH expression. Redox Biol. 2021 Aug;44:102007.
H9c2 cells 0.1 nM 24 hours Α-MSH effectively prevented Ang II-induced increase in leucine incorporation. EMBO Rep. 2024 Apr;25(4):1987-2014
Mouse lung ILC2s 10 ng/ml 3 days Α-MSH inhibited the functions of ILC2s, reducing IL-5 and IL-13 secretion Nat Commun. 2023 Sep 12;14(1):5601
H9c2 cells 0.1 nM 3 hours Α-MSH reversed the increase in JNK phosphorylation as well as in Nppb and Acta2 expression in Ang II-treated cells. EMBO Rep. 2024 Apr;25(4):1987-2014
H9c2 cells 0.1 nM 5, 15, 30, or 60 minutes Α-MSH caused a reduction in cAMP level at 5 min time point, indicating Gi-dependent coupling of the α-MSH response. EMBO Rep. 2024 Apr;25(4):1987-2014
HEM human epidermal melanocytes 100 nM 72 hours To investigate the inhibitory effect of BI2B on α-MSH-induced melanogenesis Int J Biol Sci. 2024 Feb 17;20(5):1688-1704
B16F0 mouse melanoma cells 100 nM 72 hours To investigate the inhibitory effect of BI2B on α-MSH-induced melanogenesis Int J Biol Sci. 2024 Feb 17;20(5):1688-1704
SK-Mel-28 cells 200 nM 72 hours Investigate the effect of α-MSH on melanogenesis, results showed α-MSH significantly increased melanin content Int J Mol Sci. 2023 Sep 28;24(19):14662
G-361 cells 200 nM 72 hours Investigate the effect of α-MSH on melanogenesis, results showed α-MSH significantly increased melanin content Int J Mol Sci. 2023 Sep 28;24(19):14662
B16F1 cells 200 nM 72 hours Investigate the effect of α-MSH on melanogenesis, results showed α-MSH significantly increased melanin content Int J Mol Sci. 2023 Sep 28;24(19):14662

α-MSH 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Mice HDM-induced chronic airway inflammation model Intratracheal administration 4 mg/kg Daily for 18 days Α-MSH alleviated lung inflammation, reducing the number and function of ILC2s Nat Commun. 2023 Sep 12;14(1):5601
BALB/c mice Endotoxin-induced acute hepatic inflammation Intravenous injection 50 μg Single injection, evaluated from 30 minutes to 6 hours Α-MSH prevented LPS-induced liver inflammation, inhibited systemic NO production, hepatic neutrophil infiltration, and increased hepatic mRNA abundance for TNFα, KC/IL-8, and MCP-1 J Clin Invest. 1996 May 1;97(9):2038-44

α-MSH 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.60mL

0.12mL

0.06mL

3.00mL

0.60mL

0.30mL

6.01mL

1.20mL

0.60mL

α-MSH 技术信息

CAS号581-05-5
分子式C77H109N21O19S
分子量 1664.88
SMILES Code OC1=CC=C(C[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(NCC(N[C@H](C(N4[C@H](C(N[C@@H](C(C)C)C(N)=O)=O)CCC4)=O)CCCCN)=O)=O)=O)CCCNC(N)=N)=O)CC5=CC=CC=C5)=O)CC6=CNC=N6)=O)CCC(O)=O)=O)CCSC)=O)CO)=O)NC([C@@H](NC(C)=O)CO)=O)C=C1
MDL No. MFCD00133062
别名 α-Melanocyte-Stimulating Hormone
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C
溶解方案

DMSO: 105 mg/mL(63.07 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 12 mg/mL(7.21 mM)

Tags: α-MSH | 581-05-5 | α-Melanocyte-Stimulating Hormone | Melanocortin Receptor | MC4R Agonist | GPCR/G Protein | Neuronal Signaling | Melanocortin Receptor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | α-MSH 纯度/质量文件 | α-MSH 实验方案 | α-MSH 技术信息

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