There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
α-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Inhibition of the Testosterone Metabolism in Rat Liver Slices by 17 alpha-Estradiol[3]. α-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression[4]. α-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups. α-Estradiol (1 μg) markedly decreasesmalondialdehyde (MDA) levels on postnatal days (PND) 9, 13, and 17 in retinas of hyperoxia-exposed pups. α-Estradiol (1 μg) also decreases the number of NADPH-oxidase-positive cells, NADPH oxidase concentration and activity in retinas of the pups[5]. Seventeen α-estradiol (17α-E2) increase insulin sensitivity and extend lifespan in male mice, with less robust effects in female mice. 17α-E2 treatment decreased the number of primordial follicles in GHRKO (Growth hormone receptor knockout) mice. GHRKO mice displayed lesser primordial follicle activation as compared to wild type mice, but this phenotype was reversed by 17α-E2 administration, suggesting that ovarian aging is increased by 17α-E2 in long-living mice with extended reproductive longevity[6].
α-Estradiol/α-雌二醇 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
Male mice
Dietary administration
14.4 mg/kg diet
From 4 months of age for 8 months
To investigate the effects of 17aE2 on lifespan extension in male mice and its metabolic responses. Results showed that 17aE2 significantly extended male lifespan by 19% and induced sex-specific changes in liver and plasma metabolites.
Aging Cell. 2018 Aug;17(4):e12786
Mice
UM-HET3 mice
Dietary administration
14.4 mg/kg diet
Continuous administration starting from 4 months of age
To investigate the effects of α-Estradiol on lifespan extension in male mice and its relationship with glucose tolerance and mTORC2 signaling. Results showed that α-Estradiol significantly extended male lifespan (19%) with no noticeable effects in females. Male mice exhibited improved glucose tolerance and enhanced mTORC2 signaling activity.
Aging Cell. 2017 Dec;16(6):1256-1266
UM-HET3 male mice
Genetically heterogeneous mouse model
Fed in diet
14.4 ppm
Continuously starting at either 16 or 20 months of age
Extended median male lifespan by 19% (p < 0.0001, log-rank test) and 11% (p = 0.007) when fed at 14.4 ppm starting at 16 and 20 months, respectively. 90th percentile lifespans were extended 7% (p = 0.004, Wang–Allison test) and 5% (p = 0.17). Body weights were reduced about 20% after starting the 17aE2 diets.
Aging Cell. 2021 May;20(5):e13328
Male mice
UM-HET3 mice
Dietary administration
14.4 ppm
Treatment started at 4 months of age and continued
17aE2 improved muscle weight and function in male mice, but not in females or castrated males
Aging Cell. 2019 Apr;18(2):e12920
UM-HET3 mice
Aging model
Dietary administration
14.4 ppm
Continuous administration starting from 4 months of age
To study the effect of 17-α-Estradiol on hypothalamic inflammation in male mice, results showed that at 12 months of age, 17-α-Estradiol significantly reduced hypothalamic inflammation in male mice but had no significant effect in female mice.
Aging Cell. 2017 Aug;16(4):652-660
Mice
Genetically heterogeneous mice
Diet
14.4 ppm
Continuous administration starting at 10 months of age
17aE2 robustly extended both median (19%) and maximal (12%) lifespan in male mice, but had no significant effect on female survival.
Aging Cell. 2016 Oct;15(5):872-84
Mice
Genetically heterogeneous mice
Dietary administration
4.8 mg/kg diet
Continuous administration starting from 10 months of age
To evaluate the effects of α-Estradiol on lifespan. Results showed that male median lifespan increased by 12% (P=0.002), but female lifespan was not affected.
Aging Cell. 2014 Apr;13(2):273-82
Dogs
Normal male dogs
Subcutaneous injection
5 mg
Single injection, effect lasted 48 to 72 hours
To observe the effect of α-Estradiol on electrolyte excretion, results showed a marked decrease in the renal excretion of water, sodium, chloride, inorganic phosphorus and total nitrogen, with a slight increase in potassium excretion.
J Exp Med. 1938 Aug 31;68(3):299-312
Wistar-derived rats
20-day-old female rats
I.p. injection
5 μg/rat
Single injection, measured after 24 hours
To study the effect of E2 on CK activity in female rat diaphyseal bone, results showed that E2 significantly increased CK activity by 82% within 1 hour, reaching a maximal increase of 200% after 24 hours.
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