(+)-(3R,8S)-Falcarindiol, a natural product isolated and purified from the roots of Angelica sinensis, is a potential anticancer agent that exerts its activity through inducing ER stress and apoptosis, and induces immunosuppressive effects in vitro and in vivo and might be a therapy for autoimmune or allergic diseases. It has protective effect against CCl(4) toxicity, in part, be explained by anti-lipid peroxidation activity associated with the induction of the GSTs including GSTA4.
Evaluate the safety of Falcarindiol on normal intestinal cells, results showed no significant inhibition on IEC-6 cells at 20 μM
Phytomedicine. 2013 Aug 15;20(11):999-1006.
MCF-7 cells
10 μM
48 h
Evaluate the antiproliferative effects of Falcarindiol, results showed antiproliferative effects on MCF-7 cells at 10 μM
Phytomedicine. 2013 Aug 15;20(11):999-1006.
SW-480 cells
10 μM
48 h
Evaluate the antiproliferative effects of Falcarindiol, results showed significant inhibition of SW-480 cell growth at 10 μM
Phytomedicine. 2013 Aug 15;20(11):999-1006.
HCT-116 cells
10 μM
48 h
Evaluate the antiproliferative effects of Falcarindiol, results showed almost complete inhibition of HCT-116 cell growth at 10 μM
Phytomedicine. 2013 Aug 15;20(11):999-1006.
MCF-7
7.5 µM
24 h
FAD induces caspase-3-dependent apoptosis by regulating NOX4 and ER stress signaling pathways.
Antioxidants (Basel). 2024 Dec 14;13(12):1533.
MDA-MB-231
7.5 µM
24 h
FAD induces caspase-3-dependent apoptosis by regulating NOX4 and ER stress signaling pathways.
Antioxidants (Basel). 2024 Dec 14;13(12):1533.
Rat primary astrocytes
50 μM
30 min
To investigate the inhibitory effect of falcarindiol on LPS/IFN-γ-induced iNOS expression. Results showed that falcarindiol attenuated the activation of IKK and JAK, leading to the blockade of NF-κB and Stat1 activation, thereby suppressing iNOS expression.
Br J Pharmacol. 2005 Jan;144(1):42-51.
FHs 74 Int. cells
1 ng/mL to 20 μg/mL
72 h
No hormesis effect was observed, and significant inhibition of proliferation was observed at concentrations of 1 μg/mL and above.
J Agric Food Chem. 2009 Sep 23;57(18):8290-6.
Caco-2 cells
1 ng/mL to 20 μg/mL
72 h
A hormesis effect was observed, with a 42% increase in cell proliferation at 100 ng/mL. Significant inhibition of proliferation was observed at concentrations of 2.5 μg/mL and above.
J Agric Food Chem. 2009 Sep 23;57(18):8290-6.
(+)-(3R,8S)-Falcarindiol 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Athymic nude mice
HCT-116-Luc xenograft model
Intraperitoneal injection
15 mg/kg
Once daily for 4 weeks
Evaluate the in vivo antitumor effects of Falcarindiol, results showed significant inhibition of HCT-116 tumor growth at 15 mg/kg
Phytomedicine. 2013 Aug 15;20(11):999-1006.
BALB/c nude mice
MDA-MB-231 xenograft model
Intraperitoneal injection
10 or 20 mg/kg
Twice weekly
FAD reduces tumor volume in a dose-dependent manner.
搜索
