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首页 / 抑制剂/激动剂 / PI3K/Akt/mTOR / PIKfyve

货号 产品名 纯度
A423092 APY0201

APY0201 是一种强效、高选择性的 ATP 竞争性 PIKfyve 抑制剂(IC50 = 5.2 nM),可阻断磷脂酰肌醇 3-磷酸(PtdIns3P)向 PtdIns(3,5)P2 的转化。同时,它抑制小分子 IL-12/23 的产生。

98%
A643159 psoralidin/补骨脂定

Psoralidin, a natural furanocoumarin, is isolated from Psoralea corylifolia L. with anticancer and chemopreventive properties, inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation.

99%+
A140672 Apilimod mesylate/阿匹莫德甲磺酸盐

Apilimod mesylate is a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma, and can block filoviral entry and infection. It can also down-regulates both IL-12 p35 and IL-12/IL-23 p40 at the transcriptional level, and inhibits the production of both IL-12 and IL-23 cytokines.

99%+
A149227 Apilimod/阿匹莫德

Apilimod is a PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma, and can block filoviral entry and infection. It can also down-regulates both IL-12 p35 and IL-12/IL-23 p40 at the transcriptional level, and inhibits the production of both IL-12 and IL-23 cytokines.

99%+
A1359469 Vacuolin-1

Vacuolin-1 is cell-permeable inhibitor of lysosomal exocytosis and can block the Ca2+-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. Vacuolin-1 is also PIKfyve inhibitor that inhibits late-stage autophagy by impairing lysosomal maturation.

99%+
A2288084 PIKfyve-IN-2

98%
A1810515 PIKfyve-IN-1

98%
A1671359 S07-2009

98%
A213349 YM-201636

YM-201636 is a selective PIKfyve inhibitor with IC50 of 33 nM.

99%+
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