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货号 产品名 纯度
A193586 现货 PS-48

PS48是一种PDK1激活剂,其AC50为8 μM。

99%+
A700044 现货 BX795

BX795是一种高效、选择性的PDK1抑制剂,IC50为6 nM。它还有效抑制TBK1和IKKε,IC50值分别为6 nM和41 nM。BX795阻止S6K1、AktPKCδ和GSK3β的磷酸化,但对酶如PKAPKCc-Kit和GSK3β的选择性较低。此外,BX795调节自噬

99%+
A152748 现货 OSU-03012

OSU-03012 is a potent inhibitor of recombinant PDK-1 with IC50 of 5 μM and 2-fold increase in potency over OSU-02067.

99%+
A202355 现货 GSK2334470

GSK2334470 is a PDK1 inhibitor with IC50 of ~10 nM, with no activity at other close related AGC-kinases.

99%+
A291467 现货 PS47

97%
A1230676 现货 JX06/双(吗啉硫代羰基)二硫化物

JX06 is a selective covalent PDK1 inhibitor with IC50 values of 49, 101 and 313nM for PDK-1, PDK-2 and PDK-3, respectively.

99%+
A1258083 现货 PDK4-IN-1 HCl

PDK-4 Inhibitor compound 8c HCl is an allosteric PDK-4 inhibitor with IC50 value of 84nM.

99%+
A160471 现货 PHT-427

PHT-427 is dual inhibitor of Akt and PDPK1 with Ki of 2.7 μM and 5.2 μM, respectively, targeting PH domains of Akt and PDPK1.

99%+
A1364809 (R)-PS210

98%
A1364807 PDK1-IN-RS2

98%
A1603264 LDHA/PDKs-IN-1

98%
A1603265 LDHA/PDKs-IN-2

98%
A1947711 PKD-IN-1 dihydrochloride

98%
A681266 BX-320

95+%
A1450897 RS1-PDK1 inhibitor

98%
A348390 BX-912

BX-912 is a selective inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1) with IC50 of 12 nM, showing > 10 fold selectivity over PKA, PKC, C-Kit, EGFR etc.

99%+
A1258191 PDK4-IN-1

PDK4-IN-1 is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 has antidiabetic, anticancer and anti-allergic activity[1].

98%
A1340222 PS210

PS-210 is a selective activator of PDK1 activator. It acts by binding to the PIF-pocket allosteric docking site.

98%
A277618 MP7

PDK1 inhibitor is a potent and selective inhibitor of PDK1 with potential as anticancer agent.

99+%
A1601301 Tubulin polymerization-IN-4

98%
产品名 PDK1 其他靶点 纯度
OSU-03012 ++

PDK-1, IC50: 5 μM

99%+
BX-912 +++

PDK-1, IC50: 12 nM

PKA 99%+
GSK2334470 +++

PDK-1, IC50: 10 nM

99%+
BX795 ++++

PDK-1, IC50: 6 nM

c-Kit 99%+
PHT-427 +

PDK1, Ki: 5.2 μM

Akt 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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