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货号 产品名 纯度
A248253 JH-II-127

JH-II-127 is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 values of 2.2, 6.6 and 47.7 nM for G2019S-mutant, wild-type and A2016T-mutant LRRK2, respectively.

98%+
A125109 PF-06447475

PF-06447475 is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 values of 3 nM, possessing neuroprotective activity.

99%+
A1601847 EB-42486

98%+
A1177088 PFE-360

98%
A1500046 CZC-54252 HCl

98%+
A408166 CZC-54252

CZC-54252 is a potent LRRK2 inhibitor with IC50 values of 1.28 nM and 1.85 nM for wild-type and G2019S mutant LRRK2, respecitively, possessing neuroprotective effect.

99%+
A210153 GNE-7915

GNE-7915 is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 value of 9 nM.

99%+
A369305 GNE-9605

GNE-9605 is a selective and potent LRRK2 with IC50 value of 18.7 nM.

99%+
A206371 GNE0877

GNE0877 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitor with an IC50 of 3 nM.

99%+
A269266 CZC-25146

CZC-25146 is a potent LRRK2 inhibitor with IC50 values of 4.76 and 6.87 nM for for wild-type and G2019S mutant LRRK2, respectively. It also inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2.

99%+
A142087 GSK2578215A

GSK2578215A is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 values of 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2, respectively.

99%+
A303998 MLi-2

MLi-2 is a highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity.

99%+
A281167 LRRK2-IN-1

LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 values of 6 and 13 nM for G2019S mutant and wild-type LRRK2, respectively.

99%+
A1680467 GSK2646264

98%
A1467726 PF-06371900

PF-06371900 is a selective LRRK2 inhibitor with IC50 value of 64nM.

A2288218 LRRK2-IN-6

98%
A1810532 LRRK2-IN-7

98%
A1717527 PF-06455943

98%
A2250173 (R,R)-LRRK2-IN-7

98%
A2288178 LRRK2-IN-5

98%
产品名 LRRK2 其他靶点 纯度
GNE-7915 ++++

LRRK2, Ki: 1 nM

LRRK2, IC50: 9 nM

99%+
GNE-9605 +++

LRRK2, Ki: 2 nM

LRRK2, IC50: 19 nM

99%+
GSK2578215A ++

LRRK2 (G2019S), IC50: 8.9 nM

LRRK2 (WT), IC50: 10.9 nM

99%+
URMC-099 +

LRRK2, IC50: 11 nM

99%+
PF-06447475 +++

LRRK2, IC50: 3nM

99%+
LRRK2-IN-1 ++

LRRK2 (G2019S), IC50: 6 nM

LRRK2 (WT), IC50: 13 nM

99%+
GNE0877 ++++

LRRK2, Ki: 0.7 nM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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