Linzagolix（KLH-2109; OBE-2109）是一种有效的、非肽类、口服活性的GnRH拮抗剂，用于子宫肌瘤、子宫内膜异位症和子宫腺肌症的研究。

Cetrorelix acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with IC50 of 1.21 nM.

Degarelix is a gonadotrophin-releasing hormone (GnRH) antagonist for the first-line treatment of androgen-dependent advanced prostate cancer.

Relugolix is a non-peptide, orally active gonadotropin-releasing hormone (GnRH) antagonist with IC50 of 0.33 nM in the presence of 40% fetal bovine serum. It possesses higher affinity and potent antagonistic activity compared with TAK-013.

Lecirelin is a synthetic GnRH analogue which showed a great efficacy in the treatment of bovine ovarian follicular cysts.

Elagolix sodium is an antagonist of human GnRH receptor (GnRHR) with IC50 and Ki of 0.25 nM and 3.7 nM, respectively.