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货号 产品名 纯度
A1176818 FLT3-IN-3

95%
A332881 AI-10-49

AI-10-49 is a protein-protein interaction inhibitor that selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1 with a FRET IC50 of 0.26 μM.

99%+
A1195004 BPR1K871

DBPR114 is a potent multi-kinase inhibitor with potent activities against more than 57 oncogenic kinases, including Aurora-A, FLT3, CSF1R, MET, etc. DBPR114 exhibited favorable PK profiles: a long half-life (t1/2 = 23.5 h), moderate clearance and high volume of distribution. Also DBPR114 can effectively inhibit the growth of human acute myeloid leukemia MOLM-13 and MV4-11, MIA PaCa-2, Hep3B, MKN45, Colo205, and NTUB1 solid tumor xenografts in vivo without causing significant body weight loss.

99%+
A431319 L-Pyroglutamic acid β-naphthylamide

98%+
A321872 UNC2025

UNC2025 is an inhibitor of Mer and Flt3 with IC50 of 0.8 nM and 0.74 nM, respectively.

98+%
A929501 5'-Fluoroindirubinoxime/5'-氟二异丁酮肟

5'-Fluoroindirubinoxime is an inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) with IC50 of 15 nM.

99%+
A945561 AZD2932

AZD2932 is a series of quinazoline ether inhibitor which potently inhibits VEGFR-2 and PDGFR with IC50s of 4 nM/8 nM/ 7 nM for PDGFRβ/VEGFR-2/Flt-3.

98%
A508462 Crotonoside/巴豆苷

Crotonoside is a naturally occurring active isomer of guanosine found in the seeds of Croton tiglium, which could reduce the blood pressure in rabbits and cats. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the treatment of AML.

95%
A1177300 CCT241736

CCT241736 is a dual FLT3/Aurora kinase A/B inhibitor with IC50 values of 0.035μM, 0.015μM and 0.1μM, respectively.

98%+
A469558 TG101209

TG 101209 is a potent and selective JAK2 inhibitor with IC50 of 6 nM, also inhibits Flt3 and RET with IC50 values of 25 nM and 17 nM, respectively.

99%+
A1281655 FLT3-IN-16

98%+
A1210730 GTP-14564

97%
A1600985 FLT3-IN-10

98%+
A188034 MRX-2843

MRX-2843 is an orally available small-molecule inhibitor of both MERTK and FLT3.

98%
A1371593 KG5

97%
A845930 Denfivontinib

G-749 is a FLT3 inhibitor that showed potent and sustained inhibition of the FLT3 wild type and mutants with IC50s of 0.4/0.6/3.5/7.5 nM for Wt Flt3/D835Y/MV4-11/Molm-14 respectively.

99%+
A715558 FF-10101

FLT3-IN-1 is a potent FLT3 inhibitor extracted from patent WO2015056683A1, compound example A

98%+
A207640 (Z)-SU5614

SU-5614 is an inhibitor of FLT3. In Ba/F3 and AML cell lines expressing a constitutively activated FLT3, SU-5614 exhibits significant cell growth inhibition and cell cycle arrest.

96%
A475775 Quizartinib/奎扎替尼

Quizartinib is a second-generation FLT3 inhibitor for Flt3 (ITD/WT) with IC50 of 1.1 nM/4.2 nM, being 10-fold selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R.

98%
A633839 Fluorescein-5-maleimide/荧光素-5-马来酰亚胺

Fluorescein-5-maleimide is a fluorescent thiol-reactive dye used to conjugate fluorescein to proteins (excitation: 494 nm, emission: 519 nm).

95%
产品名 FLT3 其他靶点 纯度
R406 Syk 98%
Go6976 99%+
Quizartinib +++

FLT3 (ITD), IC50: 1.1 nM

FLT3 (WT), IC50: 4.2 nM

98%
Gilteritinib ++++

FLT3, IC50: 0.29 nM

99%+
Amuvatinib +

FLT3 (D835Y), IC50: 81 nM

99%+
Pacritinib ++

FLT3, IC50: 22 nM

FLT3 (D835Y), IC50: 6 nM

97%
Dovitinib ++++

FLT3, IC50: 1 nM

c-Kit 99%+
Denfivontinib ++++

FLT3, IC50: 0.4 nM

FLT3 (D835Y), IC50: 0.4 nM

RET 99%+
TAK-659 HCl ++

FLT3, IC50: 4.6 nM

Syk 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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