Pexacerfont is a potent and selective antagonist with IC50 value of 6.1nM.

CP-376395 is a CRF1-selective antagonist. CRF1 receptor signaling regulates food and fluid intake in the drinking-in-the-dark model of binge alcohol consumption

Antalarmin (hydrochloride) 是一种非肽类促皮质素释放激素受体 1 (CRHR1) 拮抗剂，Ki 为 1 nM。