Fedratinib hydrochloride hydrate (TG-101348 hydrochloride hydrate) 是一种有效、选择性、ATP竞争性的口服JAK2抑制剂，对JAK2和JAK2V617F激酶的IC50值均为3 nM。此外，Fedratinib hydrochloride hydrate对JAK1和JAK3的选择性分别为35倍和334倍。它在癌细胞中诱导凋亡，在骨髓增殖性疾病的研究中具有潜力。

Regorafenib（BAY 73-4506）是一种口服活性和高效的多靶点受体酪氨酸激酶抑制剂，对VEGFR1/2/3、PDGFRβ、Kit、RET和Raf-1的IC50值分别为13/4.2/46、22、7、1.5和2.5 nM。Regorafenib显示出强大的抗肿瘤和抗血管生成活性。

Fedratinib（TG-101348）是一种强效、选择性、ATP竞争性和口服活性的JAK2抑制剂，对JAK2和JAK2V617F激酶的IC50值均为3 nM。菲达替尼相对于JAK1和JAK3显示出35倍和334倍的选择性。它诱导癌细胞凋亡，并具有潜在的骨髓增殖性疾病研究价值。

Pz-1 是一种有效的 RET 和 VEGFR2 受体酪氨酸激酶抑制剂，对野生型激酶的 IC50 值均小于 1 nM。

RETV804M kinase inhibitor is a selective c-RET (V804M) inhibitor with IC50 value of 20nM.

GSK3179106 is a potent, selective and gut-restricted RET kinase inhibitor with IC50 value of 0.4nM.

Blu667 is a highly potent and selective RET inhibitor with IC50 value of 0.4nM.

AD80 is a multikinase inhibitor with inhibitions on RET, RAF, SRC and S6K.

JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor, with an IC50 of 40 nM. JNJ-38158471 also inhibits Ret and Kit with IC50s of 180 and 500 nM, respectively .

AST-487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM. AST487 also inhibits RET,KDR,c-KIT,and c-ABL kinase with IC50 values below 1 μM.

CEP-32496 is an inhibitor of BRAF V600E (IC50 = 14 nM), WT (IC50 = 34 nM) and c-Raf (IC50 = 39 nM). It also exhibits certain inhibitory activity against Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2.

BBT594 is a potentreceptor tyrosine kinase RET inhibitor, used for cancer treatment.

SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase( IC50 :8 nM). SPP-86 inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling, also inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells.

BT13 acts as direct RetA agonists and interacts with GFRα1 at the allosteric site in GDNF-GFRα1-RetA complex. It was similar to NGF and ARTN in selectively promoting neurite outgrowth from the peptidergic class of adult sensory neurons in culture, but was opposite to ARTN in causing neurite elongation without affecting initiation.