XEN445

产品说明书

Print
Chemical Structure| 1515856-92-4 同义名 : -
CAS号 : 1515856-92-4
货号 : A885460
分子式 : C18H17F3N2O3
纯度 : 99%+
分子量 : 366.33
MDL号 : MFCD28166367
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(109.19 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Lipase

    endothelial lipase, IC50:0.237 μM
描述 XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.73mL

0.55mL

0.27mL

13.65mL

2.73mL

1.36mL

27.30mL

5.46mL

2.73mL
参考文献

[1]Sun S, Dean R, et al. Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice. Bioorg Med Chem. 2013 Dec 15;21(24):7724-34.

[2]Kim YT, Lee HJ, et al. Pre-treatment of porcine pulmonary xenograft with desmopressin: a novel strategy to attenuate platelet activation and systemic intravascular coagulation in an ex-vivo model of swine-to-human pulmonary xenotransplantation. Xenotransplantation. 2008 Feb;15(1):27-35.