Poloxamer188 average Mn 7,680-9,510

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Chemical Structure| 9003-11-6 同义名 : -
CAS号 : 9003-11-6
货号 : A845895
分子式 : (C3H6O.C2H4O)x
纯度 : MW7680-9510
分子量 : 0
MDL号 : MFCD00082049
存储条件：

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL，配合低频超声助溶
生物活性
描述 Poloxamer 188, a nonionic linear copolymer, exhibits surfactant properties and demonstrates anti-thrombotic, anti-inflammatory, and cytoprotective effects across various tissue injury models, making it suitable for drug delivery applications[1][2][3][4]. As a non-ionic linear copolymer, Poloxam188 has the capability of surfactant and has antithrombotic, anti-inflammatory and cytoprotective effects in the case of tissue damage.[1].
参考文献

[1]Antunes FE, et al. Gels of Pluronic F127 and nonionic surfactants from rheological characterization to controlled drug permeation. Colloids Surf B Biointerfaces. 2011 Oct 1;87(1):42-8.

[2]Lotze FP, et al. Poloxamer 188 Exerts Direct Protective Effects on Mouse Brain Microvascular Endothelial Cells in an In Vitro Traumatic Brain Injury Model. Biomedicines. 2021 Aug 19;9(8):1043.

[3]Walters TJ, et al. Poloxamer-188 reduces muscular edema after tourniquet-induced ischemia-reperfusion injury in rats. J Trauma. 2011 May;70(5):1192-7.

[4]Yan F, et al. The effect of poloxamer 188 on nanoparticle morphology, size, cancer cell uptake, and cytotoxicity. Nanomedicine. 2010 Feb;6(1):170-8.