Tarenflurbil

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Chemical Structure| 51543-40-9 同义名 : 氟比洛芬 ;(R)-Flurbiprofen; MPC7869; E7869, E 7869, E-7869, Flurizan, Furbiprofen, MPC-7869, MPC 7869, MPC7869, (R)-Flurbiprofen; Flurizan; E-7869
CAS号 : 51543-40-9
货号 : A841572
分子式 : C15H13FO2
纯度 : 99%+
分子量 : 244.26
MDL号 : MFCD00869714
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(204.7 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 (R)-Flurbiprofen is the R-enantiomer of the racemate NSAID flurbiprofen, inhibiting the binding of [3H]9-cis-RA to RXRαLBD with IC50 of 75 μM.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02438072 Depression Not Applicable Unknown December 2015 Switzerland ... 展开 >> Hôpitaux Universitaires de Genève Recruiting Genève, Switzerland, 1205 Contact: celia Lloret-Linares, MD, PhD    0041 79 55 36 389    celia.LloretLinares@hcuge.ch 收起 <<
NCT01061112 - Unknown June 2014 United States, Minnesota ... 展开 >> Clinical and Translational Science Institute Minneapolis, Minnesota, United States, 55414 收起 <<
NCT00425451 Periodontitis Phase 2 Completed - Israel ... 展开 >> Hadassah Medical Organization Jerusalem, Israel, 91120 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.09mL

0.82mL

0.41mL

20.47mL

4.09mL

2.05mL

40.94mL

8.19mL

4.09mL
参考文献

[1]Wanngren J, Ottervald J, et al. Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production. J Biol Chem. 2012 Sep 21;287(39):32640-50.

[2]You X, Zhang YW, Cet al. Retinoid X receptor-alpha mediates (R )-flurbiprofen's effect on the levels of Alzheimer's beta-amyloid. J Neurochem. 2009 Oct;111(1):142-9.