TA-01

产品说明书

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Chemical Structure| 1784751-18-3 同义名 : -
CAS号 : 1784751-18-3
货号 : A777200
分子式 : C20H12F3N3
纯度 : 99%+
分子量 : 351.32
MDL号 : MFCD30182287
存储条件：

Pure form Keep in dark place, inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(142.32 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • CK1

    CK1ε, IC50:6.4 nM

    CK1δ, IC50:6.8 nM
描述 TA-01 is recognized as a strong inhibitor of both CK1 and p38 MAPK, with IC50 values of 6.4 nM for CK1ε, 6.8 nM for CK1δ, and 6.7 nM for p38 MAPK. At a concentration of 5 μM, TA-01 shows no cytotoxicity and fully suppresses cardiogenesis, yet at lower concentrations, it can initiate cardiogenesis[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.85mL

0.57mL

0.28mL

14.23mL

2.85mL

1.42mL

28.46mL

5.69mL

2.85mL
参考文献

[1]Laco F, et al. Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling. J Mol Cell Cardiol. 2015 Mar;80:56-70.