Decanoic Acid

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Chemical Structure| 334-48-5 同义名 : 正癸酸 ;Capric acid; DA; Econosan Acid Sanitizer.; n-Decanoic acid; n-Capric acid; Decoic acid; Caprinic acid; 1-Nonanecarboxylic acid; Decylic acid
CAS号 : 334-48-5
货号 : A765305
分子式 : C10H20O2
纯度 : 98%
分子量 : 172.26
MDL号 : MFCD00004441
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 125 mg/mL(725.63 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Decanoic acid belongs to the class of organic compounds known as medium-chain fatty acids. Decanoic acid, but not the ketones β-hydroxybutryate or acetone, shows antiseizure activity in two acute ex vivo rat hippocampal slice models of epileptiform activity. It has a strong inhibitory effect on excitatory, but not inhibitory, neurotransmission in hippocampal slices. The direct inhibition of excitatory neurotransmission by decanoic acid in the brain contributes to the anti-convulsant effect of the medium chain triglyceride ketogenic diet[2]. Decanoic acid, a component of medium-chain triclycerides, contributes to seizure control through direct α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor inhibition, whereas drugs targeting lactate dehydrogenase reduce seizures through inhibition of a metabolic pathway[3]. The presence of decanoic acid, even at a low concentration (0.2 g/L), inhibited the transformation of 10-hydroxydecanoic acid to sebacic acid. Moreover, about 24-32% reduction in the decanoic acid oxidation was observed in the presence of 0.5-1.5 g/L 10-hydroxydecanoic acid[4]. Combination treatment using perampanel and dietary decanoic acid to provide enhanced seizure control[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.81mL

1.16mL

0.58mL

29.03mL

5.81mL

2.90mL

58.05mL

11.61mL

5.81mL
参考文献

[1]Chang P, et al. Seizure control by decanoic acid through direct AMPA receptor inhibition. Brain. 2016 Feb;139(Pt 2):431-43.

[2]Chang P, Augustin K, Boddum K, et al. Seizure control by decanoic acid through direct AMPA receptor inhibition. Brain. 2016;139(Pt 2):431‐443

[3]Boison D. New insights into the mechanisms of the ketogenic diet. Curr Opin Neurol. 2017;30(2):187‐192

[4]Sugiharto YEC, Lee H, Fitriana AD, et al. Effect of decanoic acid and 10-hydroxydecanoic acid on the biotransformation of methyl decanoate to sebacic acid. AMB Express. 2018;8(1):75.

[5]Augustin K, Williams S, Cunningham M, et al. Perampanel and decanoic acid show synergistic action against AMPA receptors and seizures. Epilepsia. 2018;59(11):e172‐e178