CCT129202

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Chemical Structure| 942947-93-5 同义名 : -
CAS号 : 942947-93-5
货号 : A742954
分子式 : C23H25ClN8OS
纯度 : 98%
分子量 : 497.02
MDL号 : MFCD18074522
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 1 mg/mL(2.01 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Aurora A

    Aurora A, IC50:42 nM

  • Aurora B

    Aurora B, IC50:198 nM

  • Aurora C

    Aurora C, IC50:227 nM
描述 CCT129202 is a Aurora kinase inhibitor with IC50 of 0.042 ± 0.022, 0.198 ± 0.05, and 0.227 ± 0.064 μM for Aurora A, Aurora B, and Aurora C, respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.01mL

0.40mL

0.20mL

10.06mL

2.01mL

1.01mL

20.12mL

4.02mL

2.01mL
参考文献

[1]Cheng C, Liu ZG, et al. Enhancing chemosensitivity in ABCB1- and ABCG2-overexpressing cells and cancer stem-like cells by an Aurora kinase inhibitor CCT129202. Mol Pharm. 2012 Jul 2;9(7):1971-82.

[2]Chan F, Sun C, et al. Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3147-57.