3-Deazaneplanocin A

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Chemical Structure| 102052-95-9 同义名 : 3-Deazaneplanocin; DZNep; NSC 617989
CAS号 : 102052-95-9
货号 : A741502
分子式 : C12H14N4O3
纯度 : 98+%
分子量 : 262.26
MDL号 : MFCD12545899
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 120 mg/mL(457.55 mM)，配合低频超声助溶
生物活性
描述 3-Deazaneplanocin A is an attractive epigenetic anticancer agent through the inhibition of the cellular enhancer of zeste homolog 2 (EZH2) protein.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.81mL

0.76mL

0.38mL

19.07mL

3.81mL

1.91mL

38.13mL

7.63mL

3.81mL
参考文献

[1]Avan A, Crea F, et al. Molecular mechanisms involved in the synergistic interaction of the EZH2 inhibitor 3-deazaneplanocin A with gemcitabine in pancreatic cancer cells. Mol Cancer Ther. 2012 Aug;11(8):1735-46.

[2]Fiskus W, Wang Y, et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood. 2009 Sep 24;114(13):2733-43.