PIM447

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Chemical Structure| 1210608-43-7 同义名 : LGH447
CAS号 : 1210608-43-7
货号 : A735192
分子式 : C24H23F3N4O
纯度 : 98%
分子量 : 440.46
MDL号 : MFCD30489724
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 PIM447 (LGH447) is a strong, orally administered, and specific inhibitor targeting all PIM kinases, exhibiting Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 offers both anti-myeloma and bone-protection benefits, and it triggers apoptosis[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.27mL

0.45mL

0.23mL

11.35mL

2.27mL

1.14mL

22.70mL

4.54mL

2.27mL
参考文献

[1]Burger MT, et al. Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibito

[2]Paíno T et al. The novel pan-PIM kinase inhibitor, PIM447, displays dual anti-myeloma and bone protective effects, and potently synergizes with current standards of care. Clin Cancer Res. 2016 Jul 20.