CCT241533 HCl

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Chemical Structure| 1431697-96-9 同义名 : CCT241533 (hydrochloride); CCT241533 hydrochloride
CAS号 : 1431697-96-9
货号 : A699007
分子式 : C23H28ClFN4O4
纯度 : 99%
分子量 : 478.94
MDL号 : N/A
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(219.23 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 30 mg/mL(62.64 mM)，配合低频超声助溶
生物活性
描述 CCT241533 hydrochloride is a potent serine/threonine checkpoint kinase (Chk2) inhibitor with IC50 of 3 nM and shows minimal cross-reactivity against a panel of kinases at 1 μM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.09mL

0.42mL

0.21mL

10.44mL

2.09mL

1.04mL

20.88mL

4.18mL

2.09mL
参考文献

[1]Anderson VE, Walton MI, et al. CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res. 2011 Jan 15;71(2):463-72.

[2]Caldwell JJ, Welsh EJ, et al. Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J Med Chem. 2011 Jan 27;54(2):580-90.