S0859

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Chemical Structure| 1019331-10-2 同义名 : -
CAS号 : 1019331-10-2
货号 : A676229
分子式 : C29H24ClN3O3S
纯度 : 99%
分子量 : 530.04
MDL号 : MFCD23136018
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(198.1 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 S0859, an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH (i) recovery (K (i)=1.7 mM, full inhibition at approximately 30 mM).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.89mL

0.38mL

0.19mL

9.43mL

1.89mL

0.94mL

18.87mL

3.77mL

1.89mL
参考文献

[1]Larsen AM, Krogsgaard-Larsen N, et al. Gram-scale solution-phase synthesis of selective sodium bicarbonate co-transport inhibitor S0859: in vitro efficacy studies in breast cancer cells. ChemMedChem. 2012 Oct;7(10):1808-14.

[2]Ch'en FF, Villafuerte FC, et al. S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heart. Br J Pharmacol. 2008;153(5):972-82