GSK1016790A

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Chemical Structure| 942206-85-1 同义名 : GSK101
CAS号 : 942206-85-1
货号 : A670815
分子式 : C28H32Cl2N4O6S2
纯度 : 99%+
分子量 : 655.61
MDL号 : MFCD12912413
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(53.39 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 GSK1016790A is characterized as a highly potent and selective agonist for the transient receptor potential vanilloid 4 (TRPV4) channel. It triggers Ca2+ influx and increases intracellular Ca2+ levels in HEK cells[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.53mL

0.31mL

0.15mL

7.63mL

1.53mL

0.76mL

15.25mL

3.05mL

1.53mL
参考文献

[1]Kevin S Thorneloe, et al. N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I. J Pharmacol Exp Ther. 2008 Aug;326(2):432-42.

[2]J Fichna, et al. Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission. J Mol Med (Berl). 2015 Dec;93(12):1297-309.