Blebbistatin

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Chemical Structure| 674289-55-5 同义名 : (±)-Blebbistatin
CAS号 : 674289-55-5
货号 : A611342
分子式 : C18H16N2O2
纯度 : 98%
分子量 : 292.33
MDL号 : MFCD04113775
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(85.52 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Blebbistatin, a selective non-muscle myosin II (NMII) inhibitor, enhances directional migration of corneal endothelial cells (CECs), accelerates wound healing, and preserves cell junctional integrity and barrier function. It impedes cell migration [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.42mL

0.68mL

0.34mL

17.10mL

3.42mL

1.71mL

34.21mL

6.84mL

3.42mL
参考文献

[1]Ho WT, et al. Targeting non-muscle myosin II promotes corneal endothelial migration through regulating lamellipodial dynamics. J Mol Med (Berl). 2019 Sep;97(9):1345-1357.

[2]Liang Ma, et al. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 2015 Jan;25(1):24-38.