Forodesine

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Chemical Structure| 209799-67-7 同义名 : BCX-1777; Immucillin-H
CAS号 : 209799-67-7
货号 : A608814
分子式 : C11H14N4O4
纯度 : 99%
分子量 : 266.25
MDL号 : MFCD09837827
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(394.36 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Forodesine (BCX-1777) is identified as a potent, orally active inhibitor of purine nucleoside phosphorylase (PNP), showing IC50 values ranging from 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP. It notably hinders human lymphocyte proliferation and induces apoptosis in leukemic cells by elevating dGTP levels[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.76mL

0.75mL

0.38mL

18.78mL

3.76mL

1.88mL

37.56mL

7.51mL

3.76mL
参考文献

[1]Bieghs L, et al. The effects of forodesine in murine and human multiple myeloma cells. Adv Hematol. 2010;2010:131895.

[2]Bantia S, et al. Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)--a novel potent and orally active immunosuppressive agent. Int Immunopharmacol. 2001 Jun;1(6):1199-210.