ORM-15341

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Chemical Structure| 1297537-33-7 同义名 : -
CAS号 : 1297537-33-7
货号 : A517338
分子式 : C19H17ClN6O2
纯度 : 99%
分子量 : 396.83
MDL号 : MFCD29472275
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(264.6 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.52mL

0.50mL

0.25mL

12.60mL

2.52mL

1.26mL

25.20mL

5.04mL

2.52mL
参考文献

[1]Moilanen AM, Riikonen R, et al. Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies. Sci Rep. 2015 Jul 3;5:12007.